Molecule Details
InChIKeyKWRXWPRFIUJQBP-UHFFFAOYSA-N
Compound Name4-amino-N-[4-[(3-methylphenyl)carbamoylamino]phenyl]thieno[2,3-d]pyrimidine-5-carboxamide
Canonical SMILESCc1cccc(NC(=O)Nc2ccc(NC(=O)c3csc4ncnc(N)c34)cc2)c1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)25
Pfam Stratification Cross-Family
Avg pChEMBL6.73
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (25)
Target Gene Organism Category Pfam pChEMBL Type Source
O00444 PLK4 Homo sapiens Human PF00069 PF18190 PF18409 7.9 Ki ChEMBL
Q9H2G2 SLK Homo sapiens Human PF00069 PF12474 7.7 Ki ChEMBL
O95819 MAP4K4 Homo sapiens Human PF00780 PF00069 7.6 Ki ChEMBL
P06493 CDK1 Homo sapiens Human PF00069 7.5 Ki ChEMBL
Q8TDC3 BRSK1 Homo sapiens Human PF21122 PF00069 PF21115 7.5 Ki ChEMBL
Q12851 MAP4K2 Homo sapiens Human PF00780 PF00069 7.4 Ki ChEMBL
Q9HBH9 MKNK2 Homo sapiens Human PF00069 7.2 Ki ChEMBL
Q14680 MELK Homo sapiens Human PF02149 PF00069 PF21594 7.1 Ki ChEMBL
P30530 AXL Homo sapiens Human PF00041 PF13927 PF07714 7.0 Ki ChEMBL
Q13976 PRKG1 Homo sapiens Human PF00027 PF16808 PF00069 6.8 Ki ChEMBL
Q13557 CAMK2D Homo sapiens Human PF08332 PF00069 6.7 Ki ChEMBL
Q13188 STK3 Homo sapiens Human PF11629 PF00069 6.6 Ki ChEMBL
Q7KZI7 MARK2 Homo sapiens Human PF02149 PF00069 PF00627 6.6 Ki ChEMBL
Q13237 PRKG2 Homo sapiens Human PF00027 PF00069 6.5 Ki ChEMBL
Q8N4C8 MINK1 Homo sapiens Human PF00780 PF00069 6.5 Ki ChEMBL
P00533 EGFR Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 6.4 Ki ChEMBL
P27448 MARK3 Homo sapiens Human PF02149 PF00069 PF00627 6.4 Ki ChEMBL
P52333 JAK3 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.3 Ki ChEMBL
Q8NE63 HIPK4 Homo sapiens Human PF00069 6.3 Ki ChEMBL
Q08881 ITK Homo sapiens Human PF00779 PF00169 PF07714 PF00017 PF00018 6.1 Ki ChEMBL
Q9HAZ1 CLK4 Homo sapiens Human PF00069 6.1 Ki ChEMBL
P07332 FES Homo sapiens Human PF00611 PF07714 PF00017 6.0 Ki ChEMBL
P11309 PIM1 Homo sapiens Human PF00069 6.0 Ki ChEMBL
P53667 LIMK1 Homo sapiens Human PF00412 PF00595 PF07714 6.0 Ki ChEMBL
Q16620 NTRK2 Homo sapiens Human PF07679 PF13855 PF16920 PF01462 PF07714 6.0 Ki ChEMBL