Molecule Details
InChIKeyKVGTWUGUDPNRGC-UHFFFAOYSA-N
Compound NameRet-IN-22
Canonical SMILESCC(C)(c1cc(NC(=O)Nc2ccc(-c3cc(-c4ccc(OCCN5CCOCC5)cc4)[nH]n3)cc2)no1)C(F)(F)F
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)6
Pfam Stratification Homologous
Avg pChEMBL7.24
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (6)
Target Gene Organism Category Pfam pChEMBL Type Source
P09619 PDGFRB Homo sapiens Human PF00047 PF13927 PF25305 PF07714 7.8 IC50 ChEMBL
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 7.7 IC50 ChEMBL
P10721 KIT Homo sapiens Human PF00047 PF07714 7.3 IC50 ChEMBL
Q08345 DDR1 Homo sapiens Human PF21114 PF00754 PF07714 7.2 IC50 ChEMBL
P07333 CSF1R Homo sapiens Human PF00047 PF25305 PF07714 7.0 IC50 ChEMBL
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 6.4 IC50 ChEMBL