InChIKey	KTUFNOKKBVMGRW-UHFFFAOYSA-N
Compound Name	Imatinib
Canonical SMILES	Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	38
Pfam Stratification	Cross-Family
Avg pChEMBL	6.95
Source	ChEMBL;BindingDB;TTD_MultiTarget

DrugBank ID	DB00619
Drug Name	Imatinib
CAS Number	152459-95-5
Groups	approved investigational
ATC Codes	L01EA01
Description	Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001.[A249305] It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54...

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Categories: Amides Antineoplastic Agents Antineoplastic and Immunomodulating Agents BCRP/ABCG2 Inhibitors BCRP/ABCG2 Substrates BSEP/ABCB11 Substrates Bcr-Abl Tyrosine Kinase Inhibitors Benzamides and benzamide derivatives Benzene Derivatives Cancer immunotherapy Cardiotoxic antineoplastic agents Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP2C8 Substrates Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (moderate) Cytochrome P-450 CYP2C9 Inhibitors (strength unknown) Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (weak) Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Inhibitors Cytochrome P-450 CYP3A5 Inhibitors (strength unknown) Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 CYP3A7 Inhibitors Cytochrome P-450 CYP3A7 Inhibitors (strength unknown) Cytochrome P-450 CYP3A7 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Drugs causing inadvertant photosensitivity Enzyme Inhibitors Highest Risk QTc-Prolonging Agents Immunosuppressive Agents Immunotherapy Kinase Inhibitor Myelosuppressive Agents OATP1B3 substrates OCT1 substrates OCT2 Inhibitors P-glycoprotein inhibitors P-glycoprotein substrates Photosensitizing Agents Piperazines Protein Kinase Inhibitors Pyrimidines QTc Prolonging Agents Tyrosine Kinase Inhibitors UDP Glucuronosyltransferases Inhibitors UGT2B17 Inhibitors

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Cross-references: BindingDB: 31341 ChEBI: 45783 CHEMBL941 ChemSpider: 5101 Drugs Product Database (DPD): 12429 D01441 PDB: STI PharmGKB: PA10804 PubChem:5291 PubChem:46505055 RxCUI: 282388 Therapeutic Targets Database: DNC001383 Wikipedia: Imatinib ZINC: ZINC000019632618