Molecule Details
InChIKeyKTQYQHLIMZOBSM-UHFFFAOYSA-N
Compound Name1-(4-(4-Aminoisoxazolo[5,4-d]pyrimidin-3-yl)phenyl)-3-m-tolylurea
Canonical SMILESCc1cccc(NC(=O)Nc2ccc(-c3noc4ncnc(N)c34)cc2)c1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)12
Pfam Stratification Cross-Family
Avg pChEMBL6.78
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (12)
Target Gene Organism Category Pfam pChEMBL Type Source
P17948 FLT1 Homo sapiens Human PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 8.0 Ki ChEMBL
P07333 CSF1R Homo sapiens Human PF00047 PF25305 PF07714 7.8 Ki ChEMBL
P36888 FLT3 Homo sapiens Human PF00047 PF07714 7.8 Ki ChEMBL
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 7.0 IC50 ChEMBL;BindingDB
Q9H4B4 PLK3 Homo sapiens Human PF00069 PF00659 6.7 Ki ChEMBL
Q8NE63 HIPK4 Homo sapiens Human PF00069 6.6 Ki ChEMBL
P51451 BLK Homo sapiens Human PF07714 PF00017 PF00018 6.5 Ki ChEMBL
Q9HAZ1 CLK4 Homo sapiens Human PF00069 6.5 Ki ChEMBL
O96017 CHEK2 Homo sapiens Human PF00498 PF00069 6.2 Ki ChEMBL
P06239 LCK Homo sapiens Human PF07714 PF00017 PF00018 6.2 Ki ChEMBL
P07948 LYN Homo sapiens Human PF07714 PF00017 PF00018 6.0 Ki ChEMBL
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 6.0 Ki ChEMBL