Molecule Details
| InChIKey | KSIYRLNWOATMQX-UHFFFAOYSA-N |
|---|---|
| Compound Name | 2-N-(2,3-dichlorophenyl)-5-(1-piperidin-4-ylpyrazol-4-yl)-4-N-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidine-2,4-diamine |
| Canonical SMILES | Clc1cccc(Nc2ncc(-c3cnn(C4CCNCC4)c3)c(Nc3ccc4c(c3)CNCC4)n2)c1Cl |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 3 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.48 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (3)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q12866 | MERTK | Homo sapiens | Human | PF00041 PF00047 PF13927 PF07714 | 8.4 | IC50 | ChEMBL;BindingDB |
| Q06418 | TYRO3 | Homo sapiens | Human | PF00041 PF07679 PF07714 | 7.8 | IC50 | ChEMBL;BindingDB |
| P30530 | AXL | Homo sapiens | Human | PF00041 PF13927 PF07714 | 6.3 | IC50 | ChEMBL;BindingDB |