3-(5-Iodo-1H-indol-3-yl)-4-(3,4,5-trimethoxyphenyl)-1H-pyrrole-2,5-dione

InChIKey	`KRICMVKKVCDVBV-UHFFFAOYSA-N`
Compound Name	3-(5-Iodo-1H-indol-3-yl)-4-(3,4,5-trimethoxyphenyl)-1H-pyrrole-2,5-dione
Canonical SMILES	`COc1cc(C2=C(c3c[nH]c4ccc(I)cc34)C(=O)NC2=O)cc(OC)c1OC`
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	7
Pfam Stratification	Cross-Family
Avg pChEMBL	7.15
Source	ChEMBL;BindingDB;TTD_MultiTarget

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P35968	KDR	Homo sapiens	Human	PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854	7.6	IC50	ChEMBL;BindingDB
P35916	FLT4	Homo sapiens	Human	PF07679 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854	7.5	IC50	ChEMBL;BindingDB
Q02763	TEK	Homo sapiens	Human	PF00041 PF10430 PF07714	7.4	pIC50	TTD_MultiTarget
P17948	FLT1	Homo sapiens	Human	PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854	7.2	IC50	ChEMBL;BindingDB
P09619	PDGFRB	Homo sapiens	Human	PF00047 PF13927 PF25305 PF07714	6.1	IC50	ChEMBL;BindingDB
P04626	ERBB2	Homo sapiens	Human	PF00757 PF14843 PF07714 PF01030 PF21314	Clinical	TTD_MultiTarget	TTD_MultiTarget
P06729	CD2	Homo sapiens	Human	PF05790 PF07686	Clinical	TTD_MultiTarget	TTD_MultiTarget