Molecule Details
| InChIKey | KQRMPLPRESELFZ-UHFFFAOYSA-N |
|---|---|
| Compound Name | 3-Cyclopentyl-5-{2-ethoxy-5-[4-(2-hydroxy-ethyl)-piperazine-1-sulfonyl]-phenyl}-1-methyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one |
| Canonical SMILES | CCOc1ccc(S(=O)(=O)N2CCN(CCO)CC2)cc1-c1nc(O)c2c(n1)c(C1CCCC1)nn2C |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 8.07 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| O76074 | PDE5A | Homo sapiens | Human | PF01590 PF00233 | 8.3 | IC50 | ChEMBL;BindingDB |
| P54750 | PDE1A | Homo sapiens | Human | PF00233 PF08499 | 8.0 | IC50 | ChEMBL |
| Q01064 | PDE1B | Homo sapiens | Human | PF00233 PF08499 | 8.0 | IC50 | ChEMBL;BindingDB |
| Q14123 | PDE1C | Homo sapiens | Human | PF00233 PF08499 | 8.0 | IC50 | ChEMBL |