Molecule Details
| InChIKey | KPYSYYIEGFHWSV-UHFFFAOYSA-N |
|---|---|
| Compound Name | Baclofen |
| Canonical SMILES | NCC(CC(=O)O)c1ccc(Cl)cc1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 2 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.42 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB00181 |
|---|---|
| Drug Name | Baclofen |
| CAS Number | 1134-47-0 |
| Groups | approved investigational |
| ATC Codes | M03BX01 |
| Description | Baclofen is a gamma-aminobutyric acid (GABA) agonist used as a skeletal muscle relaxant. Although originally designed in 1962 to treat epilepsy, baclofen was not effective in treating this condition but instead was shown to reduce spasticity in selected patients.[A245338] Baclofen was reintroduced i... |
Categories: Agents Causing Muscle Toxicity Amino Acids Amino Acids, Peptides, and Proteins Aminobutyrates Butyrates Central Nervous System Agents Central Nervous System Depressants Drugs that are Mainly Renally Excreted GABA Agents GABA Agonists GABA-B Receptor Agonists Gaba-derivative Skeletal Muscle Relaxants Muscle Relaxants Muscle Relaxants, Centrally Acting Agents Muscle Relaxants, Peripherally Acting Agents Musculo-Skeletal System Neurotransmitter Agents gamma-Aminobutyric Acid-ergic Agonist
Cross-references: BindingDB: 24182 ChEBI: 187893 CHEMBL701 ChemSpider: 2197 Drugs Product Database (DPD): 2104 Guide to Pharmacology: 1084 IUPHAR: 1084 D00241 PharmGKB: PA448533 PubChem:2284 PubChem:46508181 RxCUI: 1292 Therapeutic Targets Database: DAP000257 Wikipedia: Baclofen