InChIKey	KPWSJANDNDDRMB-QAQDUYKDSA-N
Canonical SMILES	CN(C)C(=O)N[C@H]1CC[C@H](CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	17
Pfam Stratification	Cross-Family
Avg pChEMBL	7.37
Source	ChEMBL;BindingDB

DrugBank ID	DB06016
Drug Name	Cariprazine
CAS Number	839712-12-8
Groups	approved investigational
ATC Codes	N05AX15
Description	Cariprazine is an atypical antipsychotic agent and a piperazine derivative that was first developed in Hungary.[A247100] It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT<sub>1A</sub> receptors and as an antagonist at serotonin 5-HT<sub>2A</sub> receptors.[L40198]...

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Categories: Agents that produce hypertension Antidepressive Agents Antipsychotic Agents Antipsychotic Agents (Second Generation [Atypical]) Central Nervous System Agents Central Nervous System Depressants Chlorobenzenes Cyclohexanes Cytochrome P-450 CYP1A2 Inhibitors Cytochrome P-450 CYP1A2 Inhibitors (weak) Cytochrome P-450 CYP2C19 Inhibitors Cytochrome P-450 CYP2C19 Inhibitors (weak) Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (weak) Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (weak) Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP2E1 Inhibitors Cytochrome P-450 CYP2E1 Inhibitors (weak) Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (weak) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Inducers Cytochrome P-450 CYP3A5 Inducers (strength unknown) Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Dopamine Agonists Dopamine D2/D3 receptor modulators Histamine Antagonists Histamine H1 Antagonists Nervous System Neurotoxic agents P-glycoprotein inhibitors Piperazines Psycholeptics Psychotropic Drugs Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome Serotonin 5-HT1 Receptor Agonists Serotonin 5-HT2 Receptor Antagonists Serotonin 5-HT2A Receptor Antagonists Serotonin 5-HT2C Receptor Antagonists Serotonin Agents Serotonin Receptor Agonists Serotonin Receptor Antagonists Tranquilizing Agents

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Cross-references: BindingDB: 707646 ChEBI: 90933 CHEMBL2028019 ChemSpider: 25999972 Drugs Product Database (DPD): 23719 D09997 PDB: 7RU PubChem:11154555 PubChem:310264859 RxCUI: 1667655 Wikipedia: Cariprazine ZINC: ZINC000100907004