Molecule Details
| InChIKey | KOZFSFOOLUUIGY-SOLYNIJKSA-N |
|---|---|
| Compound Name | K252a |
| Canonical SMILES | COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 |
| Clinical Status | Clinical Multi-Target |
| Targets (Human+Pathogen) | 88 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.11 |
| Source | BindingDB;ChEMBL;TTD_MultiTarget |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB02152 |
|---|---|
| Drug Name | K-252a |
| CAS Number | 97161-97-2 |
| Groups | experimental |
| ATC Codes | nan |
| Description | nan |
Categories: Alkaloids Enzyme Inhibitors Heterocyclic Compounds, Fused-Ring Indoles Indolizidines Indolizines Protein Kinase C, antagonists & inhibitors
Cross-references: BindingDB: 6760 ChEBI: 43616 CHEMBL281948 ChemSpider: 2299962 Guide to Pharmacology: 336 IUPHAR: 336 PDB: KSA PubChem:3035817 PubChem:46504455 ZINC: ZINC000003872984
Target Activities (88)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P15735 | PHKG2 | Homo sapiens | Human | PF00069 | 8.8 | IC50 | ChEMBL |
| P46019 | PHKA2 | Homo sapiens | Human | PF00723 PF19292 | 8.8 | IC50 | ChEMBL |
| P46020 | PHKA1 | Homo sapiens | Human | PF00723 PF19292 | 8.8 | IC50 | ChEMBL |
| Q16816 | PHKG1 | Homo sapiens | Human | PF00069 | 8.8 | IC50 | ChEMBL |
| Q93100 | PHKB | Homo sapiens | Human | PF00723 PF19292 | 8.8 | IC50 | ChEMBL |
| Q8TDX7 | NEK7 | Homo sapiens | Human | PF00069 | 8.5 | Kd | ChEMBL |
| Q2M2I8 | AAK1 | Homo sapiens | Human | PF00069 | 8.3 | Kd | ChEMBL |
| Q16584 | MAP3K11 | Homo sapiens | Human | PF07714 PF14604 | 8.1 | IC50 | ChEMBL;BindingDB |
| Q9NWZ3 | IRAK4 | Homo sapiens | Human | PF07714 | 8.1 | Kd | ChEMBL |
| P49759 | CLK1 | Homo sapiens | Human | PF00069 | 8.0 | Kd | ChEMBL |
| Q9UKE5 | TNIK | Homo sapiens | Human | PF00780 PF00069 | 8.0 | Kd | ChEMBL |
| P04629 | NTRK1 | Homo sapiens | Human | PF13855 PF16920 PF07714 PF18613 | 7.9 | IC50 | ChEMBL;BindingDB |
| Q9HAZ1 | CLK4 | Homo sapiens | Human | PF00069 | 7.8 | Kd | ChEMBL |
| O75460 | ERN1 | Homo sapiens | Human | PF00069 PF06479 | 7.7 | Kd | ChEMBL |
| O95819 | MAP4K4 | Homo sapiens | Human | PF00780 PF00069 | 7.7 | Kd | ChEMBL |
| O14965 | AURKA | Homo sapiens | Human | PF00069 | 7.7 | Kd | ChEMBL |
| P11802 | CDK4 | Homo sapiens | Human | PF00069 | 7.7 | IC50 | ChEMBL;BindingDB |
| Q15746 | MYLK | Homo sapiens | Human | PF16620 PF00041 PF07679 PF00069 | 7.7 | IC50 | ChEMBL;BindingDB |
| Q6ZSR9 | Homo sapiens | Human | PF15282 | 7.7 | Kd | ChEMBL | |
| P80192 | MAP3K9 | Homo sapiens | Human | PF07714 PF14604 | 7.7 | IC50 | BindingDB |
| Q96L34 | MARK4 | Homo sapiens | Human | PF02149 PF00069 PF00627 | 7.5 | Kd | ChEMBL |
| Q13043 | STK4 | Homo sapiens | Human | PF11629 PF00069 | 7.5 | Kd | ChEMBL |
| P33981 | TTK | Homo sapiens | Human | PF00069 | 7.5 | Kd | ChEMBL |
| Q9BZL6 | PRKD2 | Homo sapiens | Human | PF00130 PF00169 PF00069 PF25525 | 7.5 | Kd | ChEMBL |
| Q00526 | CDK3 | Homo sapiens | Human | PF00069 | 7.5 | Kd | ChEMBL |
| P18505 | GABRB1 | Homo sapiens | Human | PF02931 PF02932 | 7.5 | pIC50 | TTD_MultiTarget |
| Q15139 | PRKD1 | Homo sapiens | Human | PF00130 PF00169 PF00069 PF25525 | 7.5 | IC50 | ChEMBL |
| O94806 | PRKD3 | Homo sapiens | Human | PF00130 PF00169 PF00069 PF25525 | 7.4 | IC50 | ChEMBL |
| Q12866 | MERTK | Homo sapiens | Human | PF00041 PF00047 PF13927 PF07714 | 7.4 | Kd | ChEMBL |
| P35968 | KDR | Homo sapiens | Human | PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 | 7.4 | IC50 | ChEMBL;BindingDB |
| Q13188 | STK3 | Homo sapiens | Human | PF11629 PF00069 | 7.4 | Kd | ChEMBL |
| P05129 | PRKCG | Homo sapiens | Human | PF00130 PF00168 PF00069 PF00433 | 7.3 | IC50 | ChEMBL |
| P05771 | PRKCB | Homo sapiens | Human | PF00130 PF00168 PF00069 PF00433 | 7.3 | IC50 | ChEMBL |
| P17252 | PRKCA | Homo sapiens | Human | PF00130 PF00168 PF00069 PF00433 | 7.3 | IC50 | ChEMBL;BindingDB |
| P24723 | PRKCH | Homo sapiens | Human | PF00130 PF00168 PF00069 PF00433 | 7.3 | IC50 | ChEMBL |
| P41743 | PRKCI | Homo sapiens | Human | PF00130 PF00564 PF00069 PF00433 | 7.3 | IC50 | ChEMBL |
| Q02156 | PRKCE | Homo sapiens | Human | PF00130 PF00168 PF00069 PF00433 | 7.3 | IC50 | ChEMBL |
| Q02779 | MAP3K10 | Homo sapiens | Human | PF07714 PF14604 | 7.3 | IC50 | BindingDB |
| Q05513 | PRKCZ | Homo sapiens | Human | PF00130 PF00564 PF00069 PF00433 | 7.3 | IC50 | ChEMBL |
| Q05655 | PRKCD | Homo sapiens | Human | PF00130 PF21494 PF00069 PF00433 | 7.3 | IC50 | ChEMBL |
| Q9H0K1 | SIK2 | Homo sapiens | Human | PF00069 PF23312 | 7.2 | Kd | ChEMBL |
| O95835 | LATS1 | Homo sapiens | Human | PF00069 PF00433 PF00627 | 7.2 | Kd | ChEMBL |
| O00444 | PLK4 | Homo sapiens | Human | PF00069 PF18190 PF18409 | 7.1 | Kd | ChEMBL |
| Q96Q04 | LMTK3 | Homo sapiens | Human | PF07714 | 7.1 | IC50 | ChEMBL |
| Q14680 | MELK | Homo sapiens | Human | PF02149 PF00069 PF21594 | 7.1 | Kd | ChEMBL |
| P52564 | MAP2K6 | Homo sapiens | Human | PF00069 | 7.1 | Kd | ChEMBL |
| Q9NSY1 | BMP2K | Homo sapiens | Human | PF15282 PF00069 | 7.0 | Kd | ChEMBL |
| Q32MK0 | MYLK3 | Homo sapiens | Human | PF00069 | 7.0 | Kd | ChEMBL |
| P24941 | CDK2 | Homo sapiens | Human | PF00069 | 7.0 | pIC50 | TTD_MultiTarget |
| Q6PHR2 | ULK3 | Homo sapiens | Human | PF04212 PF00069 | 7.0 | Kd | ChEMBL |
| O14757 | CHEK1 | Homo sapiens | Human | PF00069 | 6.9 | Kd | ChEMBL |
| Q04759 | PRKCQ | Homo sapiens | Human | PF00130 PF21494 PF00069 PF00433 | 6.9 | IC50 | ChEMBL;BindingDB |
| Q12851 | MAP4K2 | Homo sapiens | Human | PF00780 PF00069 | 6.9 | Kd | ChEMBL |
| P11309 | PIM1 | Homo sapiens | Human | PF00069 | 6.8 | IC50 | BindingDB |
| Q8TD08 | MAPK15 | Homo sapiens | Human | PF00069 | 6.8 | Kd | ChEMBL |
| Q13555 | CAMK2G | Homo sapiens | Human | PF08332 PF00069 | 6.8 | Kd | ChEMBL |
| Q99683 | MAP3K5 | Homo sapiens | Human | PF19039 PF20309 PF20302 PF13281 PF00069 | 6.7 | Kd | ChEMBL |
| Q13557 | CAMK2D | Homo sapiens | Human | PF08332 PF00069 | 6.7 | Kd | ChEMBL |
| Q9Y4K4 | MAP4K5 | Homo sapiens | Human | PF00780 PF00069 | 6.7 | Kd | ChEMBL |
| P36888 | FLT3 | Homo sapiens | Human | PF00047 PF07714 | 6.6 | Kd | ChEMBL |
| Q9Y616 | IRAK3 | Homo sapiens | Human | PF00531 PF00069 | 6.6 | Kd | ChEMBL |
| Q16512 | PKN1 | Homo sapiens | Human | PF02185 PF00069 PF00433 | 6.6 | Kd | ChEMBL |
| Q13470 | TNK1 | Homo sapiens | Human | PF07714 PF22931 | 6.5 | Kd | ChEMBL |
| O95382 | MAP3K6 | Homo sapiens | Human | PF19039 PF20309 PF20302 PF13281 PF00069 | 6.5 | Kd | ChEMBL |
| O96013 | PAK4 | Homo sapiens | Human | PF00786 PF00069 | 6.5 | Kd | ChEMBL |
| P54619 | PRKAG1 | Homo sapiens | Human | PF00571 | 6.5 | Kd | ChEMBL |
| Q96GD4 | AURKB | Homo sapiens | Human | PF00069 | 6.5 | Kd | ChEMBL |
| Q16513 | PKN2 | Homo sapiens | Human | PF02185 PF00069 PF00433 | 6.4 | Kd | ChEMBL |
| P27448 | MARK3 | Homo sapiens | Human | PF02149 PF00069 PF00627 | 6.4 | Kd | ChEMBL |
| Q00534 | CDK6 | Homo sapiens | Human | PF00069 | 6.4 | Kd | ChEMBL |
| O75676 | RPS6KA4 | Homo sapiens | Human | PF00069 PF00433 | 6.4 | Kd | ChEMBL |
| P16234 | PDGFRA | Homo sapiens | Human | PF07679 PF25305 PF07714 | 6.4 | IC50 | BindingDB |
| P16591 | FER | Homo sapiens | Human | PF00611 PF07714 PF00017 | 6.3 | Kd | ChEMBL |
| Q13131 | PRKAA1 | Homo sapiens | Human | PF16579 PF21147 PF00069 | 6.3 | Kd | ChEMBL |
| Q92918 | MAP4K1 | Homo sapiens | Human | PF00780 PF00069 | 6.3 | Kd | ChEMBL |
| O94804 | STK10 | Homo sapiens | Human | PF00069 PF12474 | 6.3 | Kd | ChEMBL |
| P36507 | MAP2K2 | Homo sapiens | Human | PF00069 | 6.3 | Kd | ChEMBL |
| Q14164 | IKBKE | Homo sapiens | Human | PF00069 PF18394 PF18396 | 6.3 | Kd | ChEMBL |
| O43353 | RIPK2 | Homo sapiens | Human | PF00619 PF07714 | 6.3 | Kd | ChEMBL |
| P43405 | SYK | Homo sapiens | Human | PF07714 PF00017 | 6.3 | Kd | ChEMBL |
| P45983 | MAPK8 | Homo sapiens | Human | PF00069 | 6.3 | Kd | ChEMBL |
| P07949 | RET | Homo sapiens | Human | PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 | 6.2 | Kd | ChEMBL |
| Q7KZI7 | MARK2 | Homo sapiens | Human | PF02149 PF00069 PF00627 | 6.2 | Kd | ChEMBL |
| Q9UGJ0 | PRKAG2 | Homo sapiens | Human | PF00571 | 6.1 | Kd | ChEMBL |
| Q00535 | CDK5 | Homo sapiens | Human | PF00069 | 6.0 | Kd | ChEMBL |
| Q76MJ5 | ERN2 | Homo sapiens | Human | PF00069 PF06479 | 6.0 | Kd | ChEMBL |
| P45984 | MAPK9 | Homo sapiens | Human | PF00069 | 6.0 | Kd | ChEMBL |
| P09619 | PDGFRB | Homo sapiens | Human | PF00047 PF13927 PF25305 PF07714 | 6.0 | Kd | ChEMBL |