Molecule Details
InChIKeyKOHNRDPXFDZZJF-UHFFFAOYSA-N
Compound Name2-Amino-3-(4-phenyl-1,3-thiazol-2-yl)benzimidazole-5-carbonitrile
Canonical SMILESN#Cc1ccc2nc(N)n(-c3nc(-c4ccccc4)cs3)c2c1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)31
Pfam Stratification Cross-Family
Avg pChEMBL6.97
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (31)
Target Gene Organism Category Pfam pChEMBL Type Source
P36888 FLT3 Homo sapiens Human PF00047 PF07714 8.5 Ki ChEMBL
P00519 ABL1 Homo sapiens Human PF08919 PF07714 PF00017 PF00018 8.0 Ki ChEMBL
Q9HAZ1 CLK4 Homo sapiens Human PF00069 8.0 Ki ChEMBL
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 7.9 Ki ChEMBL
P17948 FLT1 Homo sapiens Human PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 7.8 Ki ChEMBL
P78368 CSNK1G2 Homo sapiens Human PF12605 PF00069 7.6 Ki ChEMBL
Q9HCP0 CSNK1G1 Homo sapiens Human PF12605 PF00069 7.5 Ki ChEMBL
Q9Y6M4 CSNK1G3 Homo sapiens Human PF12605 PF00069 7.4 Ki ChEMBL
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 7.3 Ki ChEMBL
Q13627 DYRK1A Homo sapiens Human PF00069 7.3 Ki ChEMBL
Q96GD4 AURKB Homo sapiens Human PF00069 7.3 Ki ChEMBL
P22607 FGFR3 Homo sapiens Human PF21165 PF07679 PF13927 PF07714 7.2 Ki ChEMBL
P68400 CSNK2A1 Homo sapiens Human PF00069 7.2 Ki ChEMBL
Q9H2G2 SLK Homo sapiens Human PF00069 PF12474 7.2 Ki ChEMBL
P11362 FGFR1 Homo sapiens Human PF07679 PF00047 PF07714 7.1 Ki ChEMBL
P48730 CSNK1D Homo sapiens Human PF00069 7.1 Ki ChEMBL
P16591 FER Homo sapiens Human PF00611 PF07714 PF00017 6.7 Ki ChEMBL
Q12851 MAP4K2 Homo sapiens Human PF00780 PF00069 6.7 Ki ChEMBL
P00533 EGFR Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 6.6 Ki ChEMBL
P06239 LCK Homo sapiens Human PF07714 PF00017 PF00018 6.6 Ki ChEMBL
Q9BZL6 PRKD2 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.5 Ki ChEMBL
Q9NWZ3 IRAK4 Homo sapiens Human PF07714 6.5 Ki ChEMBL
P04626 ERBB2 Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 6.4 Ki ChEMBL
P07333 CSF1R Homo sapiens Human PF00047 PF25305 PF07714 6.4 Ki ChEMBL
Q9UM73 ALK Homo sapiens Human PF12810 PF00629 PF07714 6.4 Ki ChEMBL
P07948 LYN Homo sapiens Human PF07714 PF00017 PF00018 6.3 Ki ChEMBL
P43405 SYK Homo sapiens Human PF07714 PF00017 6.3 Ki ChEMBL
P49760 CLK2 Homo sapiens Human PF00069 6.2 Ki ChEMBL
P10721 KIT Homo sapiens Human PF00047 PF07714 6.1 Ki ChEMBL
P51451 BLK Homo sapiens Human PF07714 PF00017 PF00018 6.0 Ki ChEMBL
Q15303 ERBB4 Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 6.0 Ki ChEMBL