2-(((3R,4S)-3-fluoro-1-((S)-2-hydroxypropanoyl)piperidin-4-yl)oxy)-5-(4-((5-(hydroxymethyl)-1-methyl-1H-pyrazol-4-yl)amino)-1,3,5-triazin-2-yl)benzonitrile

InChIKey	`KLUCDSGOLCBPFE-OWZDWXTDSA-N`
Compound Name	2-(((3R,4S)-3-fluoro-1-((S)-2-hydroxypropanoyl)piperidin-4-yl)oxy)-5-(4-((5-(hydroxymethyl)-1-methyl-1H-pyrazol-4-yl)amino)-1,3,5-triazin-2-yl)benzonitrile
Canonical SMILES	`C[C@H](O)C(=O)N1CC[C@H](Oc2ccc(-c3ncnc(Nc4cnn(C)c4CO)n3)cc2C#N)[C@H](F)C1`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	3
Pfam Stratification	Cross-Family
Avg pChEMBL	6.65
Source	BindingDB;ChEMBL

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
Q9UHD2	TBK1	Homo sapiens	Human	PF00069 PF18394 PF18396	7.0	IC50	ChEMBL;BindingDB
Q14164	IKBKE	Homo sapiens	Human	PF00069 PF18394 PF18396	6.9	IC50	BindingDB
O60674	JAK2	Homo sapiens	Human	PF18379 PF18377 PF17887 PF07714 PF21990	6.0	IC50	BindingDB