Molecule Details
InChIKeyKLQFQJDEPBUNAK-SSDOTTSWSA-N
Compound Name5-(4-amino-1-((R)-1-aminopropan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorophenol
Canonical SMILESC[C@H](CN)n1nc(-c2ccc(F)c(O)c2)c2c(N)ncnc21
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)6
Pfam Stratification Cross-Family
Avg pChEMBL6.55
SourceChEMBL;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
Target Activities (6)
Target Gene Organism Category Pfam pChEMBL Type Source
P12931 SRC Homo sapiens Human PF07714 PF00017 PF00018 7.0 IC50 ChEMBL
P08631 HCK Homo sapiens Human PF07714 PF00017 PF00018 6.8 IC50 ChEMBL
P00519 ABL1 Homo sapiens Human PF08919 PF07714 PF00017 PF00018 6.7 IC50 ChEMBL
P18505 GABRB1 Homo sapiens Human PF02931 PF02932 6.7 pIC50 TTD_MultiTarget
P48736 PIK3CG Homo sapiens Human PF00454 PF00792 PF00794 PF00613 PF19710 6.1 IC50 ChEMBL
P54760 EPHB4 Homo sapiens Human PF14575 PF25599 PF01404 PF07699 PF00041 PF07714 PF00536 6.0 IC50 ChEMBL