n-{4-[4-Amino-7-(4-pyridinyl)thieno[3,2-c]pyridin-3-yl]phenyl}-n'-[2-fluoro-5-(trifluoromethyl)phenyl]urea

Molecule Details

InChIKey	`KKYPRNBBPBRJQX-UHFFFAOYSA-N`
Compound Name	n-{4-[4-Amino-7-(4-pyridinyl)thieno[3,2-c]pyridin-3-yl]phenyl}-n'-[2-fluoro-5-(trifluoromethyl)phenyl]urea
Canonical SMILES	`Nc1ncc(-c2ccncc2)c2scc(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c12`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	40
Pfam Stratification	Cross-Family
Avg pChEMBL	7.18
Source	ChEMBL

2D Structure

Activity Profile

Target Activities (40)

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P04629	NTRK1	Homo sapiens	Human	PF13855 PF16920 PF07714 PF18613	8.6	Ki	ChEMBL
P17948	FLT1	Homo sapiens	Human	PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854	8.5	Ki	ChEMBL
P00519	ABL1	Homo sapiens	Human	PF08919 PF07714 PF00017 PF00018	8.0	Ki	ChEMBL
P07948	LYN	Homo sapiens	Human	PF07714 PF00017 PF00018	8.0	Ki	ChEMBL
Q16620	NTRK2	Homo sapiens	Human	PF07679 PF13855 PF16920 PF01462 PF07714	8.0	Ki	ChEMBL
P35968	KDR	Homo sapiens	Human	PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854	7.9	Ki	ChEMBL
Q96GD4	AURKB	Homo sapiens	Human	PF00069	7.9	Ki	ChEMBL
P36888	FLT3	Homo sapiens	Human	PF00047 PF07714	7.8	Ki	ChEMBL
O60674	JAK2	Homo sapiens	Human	PF18379 PF18377 PF17887 PF07714 PF21990	7.7	Ki	ChEMBL
P07333	CSF1R	Homo sapiens	Human	PF00047 PF25305 PF07714	7.7	Ki	ChEMBL
P11362	FGFR1	Homo sapiens	Human	PF07679 PF00047 PF07714	7.7	Ki	ChEMBL
P06239	LCK	Homo sapiens	Human	PF07714 PF00017 PF00018	7.6	Ki	ChEMBL
P06241	FYN	Homo sapiens	Human	PF07714 PF00017 PF00018	7.6	Ki	ChEMBL
P23443	RPS6KB1	Homo sapiens	Human	PF00069 PF00433	7.6	Ki	ChEMBL
Q9UM73	ALK	Homo sapiens	Human	PF12810 PF00629 PF07714	7.6	Ki	ChEMBL
P51451	BLK	Homo sapiens	Human	PF07714 PF00017 PF00018	7.5	Ki	ChEMBL
O00444	PLK4	Homo sapiens	Human	PF00069 PF18190 PF18409	7.3	Ki	ChEMBL
P22607	FGFR3	Homo sapiens	Human	PF21165 PF07679 PF13927 PF07714	7.3	Ki	ChEMBL
P29317	EPHA2	Homo sapiens	Human	PF14575 PF25599 PF01404 PF00041 PF07714 PF00536	7.3	Ki	ChEMBL
P10721	KIT	Homo sapiens	Human	PF00047 PF07714	7.2	Ki	ChEMBL
P12931	SRC	Homo sapiens	Human	PF07714 PF00017 PF00018	7.2	Ki	ChEMBL
P35916	FLT4	Homo sapiens	Human	PF07679 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854	7.2	Ki	ChEMBL
Q08881	ITK	Homo sapiens	Human	PF00779 PF00169 PF07714 PF00017 PF00018	7.2	Ki	ChEMBL
Q9H4B4	PLK3	Homo sapiens	Human	PF00069 PF00659	7.1	Ki	ChEMBL
O14965	AURKA	Homo sapiens	Human	PF00069	7.0	Ki	ChEMBL
P51812	RPS6KA3	Homo sapiens	Human	PF00069 PF00433	6.8	Ki	ChEMBL
P52333	JAK3	Homo sapiens	Human	PF18379 PF18377 PF17887 PF07714 PF21990	6.8	Ki	ChEMBL
Q7KZI7	MARK2	Homo sapiens	Human	PF02149 PF00069 PF00627	6.8	Ki	ChEMBL
O15264	MAPK13	Homo sapiens	Human	PF00069	6.7	Ki	ChEMBL
Q13188	STK3	Homo sapiens	Human	PF11629 PF00069	6.7	Ki	ChEMBL
P27448	MARK3	Homo sapiens	Human	PF02149 PF00069 PF00627	6.6	Ki	ChEMBL
P45984	MAPK9	Homo sapiens	Human	PF00069	6.6	Ki	ChEMBL
P08581	MET	Homo sapiens	Human	PF07714 PF01437 PF01403 PF01833	6.5	Ki	ChEMBL
O15530	PDPK1	Homo sapiens	Human	PF14593 PF00069	6.4	Ki	ChEMBL
Q13464	ROCK1	Homo sapiens	Human	PF25346 PF00069 PF08912	6.4	Ki	ChEMBL
P48730	CSNK1D	Homo sapiens	Human	PF00069	6.2	Ki	ChEMBL
Q9HBY8	SGK2	Homo sapiens	Human	PF00069 PF00433	6.2	Ki	ChEMBL
P51955	NEK2	Homo sapiens	Human	PF00069	6.1	Ki	ChEMBL
P49841	GSK3B	Homo sapiens	Human	PF00069	6.0	Ki	ChEMBL
P53667	LIMK1	Homo sapiens	Human	PF00412 PF00595 PF07714	6.0	Ki	ChEMBL