Molecule Details
| InChIKey | KKKRKRMVJRHDMG-UHFFFAOYSA-N |
|---|---|
| Compound Name | R-1487 |
| Canonical SMILES | Cn1c(=O)c(Oc2ccc(F)cc2F)cc2cnc(NC3CCOCC3)nc21 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 14 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.17 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB06518 |
|---|---|
| Drug Name | R-1487 |
| CAS Number | 449811-92-1 |
| Groups | experimental |
| ATC Codes | nan |
| Description | nan |
Categories: Mitogen-Activated Protein Kinase 14, antagonists & inhibitors Pyridines
Cross-references: BindingDB: 50341342 CHEMBL1230122 ChemSpider: 9581485 PDB: 3FN ZINC: ZINC000058633224
Target Activities (14)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q16539 | MAPK14 | Homo sapiens | Human | PF00069 | 8.8 | IC50 | ChEMBL;BindingDB |
| P53779 | MAPK10 | Homo sapiens | Human | PF00069 | 8.5 | Kd | ChEMBL;BindingDB |
| Q9UBE8 | NLK | Homo sapiens | Human | PF00069 | 8.2 | Kd | ChEMBL;BindingDB |
| P45984 | MAPK9 | Homo sapiens | Human | PF00069 | 8.1 | Kd | ChEMBL;BindingDB |
| P45983 | MAPK8 | Homo sapiens | Human | PF00069 | 7.5 | Kd | ChEMBL;BindingDB |
| Q15759 | MAPK11 | Homo sapiens | Human | PF00069 | 7.5 | Kd | ChEMBL;BindingDB |
| O75676 | RPS6KA4 | Homo sapiens | Human | PF00069 PF00433 | 7.1 | Kd | ChEMBL;BindingDB |
| P51812 | RPS6KA3 | Homo sapiens | Human | PF00069 PF00433 | 6.8 | Kd | ChEMBL;BindingDB |
| Q08345 | DDR1 | Homo sapiens | Human | PF21114 PF00754 PF07714 | 6.6 | Kd | ChEMBL;BindingDB |
| Q8NI60 | COQ8A | Homo sapiens | Human | PF03109 | 6.5 | Kd | ChEMBL;BindingDB |
| Q9NRP7 | STK36 | Homo sapiens | Human | PF13646 PF00069 | 6.5 | Kd | ChEMBL;BindingDB |
| O14976 | GAK | Homo sapiens | Human | PF00069 PF10409 | 6.2 | Kd | ChEMBL;BindingDB |
| P28482 | MAPK1 | Homo sapiens | Human | PF00069 | 6.0 | Ki | ChEMBL |
| P48730 | CSNK1D | Homo sapiens | Human | PF00069 | 6.0 | Ki | ChEMBL |
DrugBank Target Actions (1)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | inhibitor | targets |