InChIKey	KJHKTHWMRKYKJE-SUGCFTRWSA-N
Compound Name	Lopinavir
Canonical SMILES	Cc1cccc(C)c1OCC(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C[C@H](Cc1ccccc1)NC(=O)[C@H](C(C)C)N1CCCNC1=O
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	4
Pfam Stratification	Cross-Family
Avg pChEMBL	9.29
Source	BindingDB;ChEMBL

DrugBank ID	DB01601
Drug Name	Lopinavir
CAS Number	192725-17-0
Groups	approved investigational
ATC Codes	J05AR10
Description	Lopinavir is an antiretroviral protease inhibitor used in combination with other antiretrovirals in the treatment of HIV-1 infection.[L11163] Lopinavir is marketed and administered exclusively in combination with [ritonavir] - this combination, first marketed by Abbott under the brand name Kaletra i...

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Categories: Anti-HIV Agents Anti-Infective Agents Anti-Retroviral Agents Antiinfectives for Systemic Use Antiviral Agents Antivirals for Systemic Use Antivirals used in combination for the treatment of HIV infections BSEP/ABCB11 Inhibitors Cytochrome P-450 CYP1A2 Inhibitors Cytochrome P-450 CYP1A2 Inhibitors (strength unknown) Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP2B6 Inhibitors Cytochrome P-450 CYP2B6 Inhibitors (strength unknown) Cytochrome P-450 CYP2B6 Inhibitors (weak) Cytochrome P-450 CYP2C19 Inhibitors Cytochrome P-450 CYP2C19 Inhibitors (weak) Cytochrome P-450 CYP2C9 Inducers Cytochrome P-450 CYP2C9 Inducers (strength unknown) Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (weak) Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strong) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Direct Acting Antivirals Enzyme Inhibitors Experimental Unapproved Treatments for COVID-19 HIV Protease Inhibitors Hyperglycemia-Associated Agents Nephrotoxic agents OATP1B1/SLCO1B1 Inhibitors OATP1B3 inhibitors Organic Anion Transporting Polypeptide 1B1 Inhibitors P-glycoprotein inducers P-glycoprotein inhibitors Potential QTc-Prolonging Agents Protease Inhibitors Pyrimidinones QTc Prolonging Agents Viral Protease Inhibitors

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Cross-references: BindingDB: 578 ChEBI: 31781 CHEMBL729 ChemSpider: 83706 Drugs Product Database (DPD): 12093 C12871 D01425 PDB: AB1 PharmGKB: PA450264 PubChem:92727 PubChem:46508588 RxCUI: 195088 Therapeutic Targets Database: DAP000708 Wikipedia: Lopinavir ZINC: ZINC000003951740