InChIKey	KJADKKWYZYXHBB-XBWDGYHZSA-N
Compound Name	Topiramate
Canonical SMILES	CC1(C)O[C@@H]2[C@@H](CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@@H]23)O1
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	15
Pfam Stratification	Cross-Family
Avg pChEMBL	7.31
Source	BindingDB;ChEMBL;TTD_MultiTarget

DrugBank ID	DB00273
Drug Name	Topiramate
CAS Number	97240-79-4
Groups	approved investigational
ATC Codes	A08AA51 N03AX11
Description	Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines.[A175249] It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults.[A188309,L10544,L43478] Since 2012, the extended-release formulation has been approved i...

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Categories: Alimentary Tract and Metabolism Anti-Obesity Agents Anticonvulsants Antiobesity Preparations, Excl. Diet Products Carbohydrates Central Nervous System Agents Central Nervous System Depressants Centrally Acting Antiobesity Products Cytochrome P-450 CYP2C19 Inhibitors Cytochrome P-450 CYP2C19 inhibitors (strength unknown) Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Inducers (weak) Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Decreased Central Nervous System Disorganized Electrical Activity Drugs that are Mainly Renally Excreted Enzyme Inducing Antiepileptic Drugs Hexoses Ketoses Miscellaneous Anticonvulsants Monosaccharides Nervous System Neuroprotective Agents P-glycoprotein substrates

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Cross-references: BindingDB: 10887 ChEBI: 63631 CHEMBL220492 ChemSpider: 4447672 Drugs Product Database (DPD): 11384 C07502 D00537 PDB: TOR PharmGKB: PA451728 PubChem:5284627 PubChem:46508334 RxCUI: 38404 Therapeutic Targets Database: DAP000137 Wikipedia: Topiramate ZINC: ZINC000095616603