Molecule Details
InChIKeyKGVGNTCIQIYLQU-UHFFFAOYSA-N
Compound Name2,2,4-Trimethyl-5-phenyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Canonical SMILESCC1=CC(C)(C)Nc2ccc3c(c21)C(c1ccccc1)Oc1ccccc1-3
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)9
Pfam Stratification Cross-Family
Avg pChEMBL6.71
SourceChEMBL;BindingDB;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
Target Activities (9)
Target Gene Organism Category Pfam pChEMBL Type Source
P06401 PGR Homo sapiens Human PF00104 PF02161 PF00105 8.4 Ki ChEMBL;BindingDB
P04150 NR3C1 Homo sapiens Human PF02155 PF00104 PF00105 6.7 IC50 ChEMBL;BindingDB
P03372 ESR1 Homo sapiens Human PF12743 PF00104 PF02159 PF00105 6.5 IC50 ChEMBL
P18505 GABRB1 Homo sapiens Human PF02931 PF02932 6.5 pIC50 TTD_MultiTarget
Q5VT25 CDC42BPA Homo sapiens Human PF00130 PF00780 PF08826 PF15796 PF25346 PF00069 PF00433 6.5 pIC50 TTD_MultiTarget
Q92731 ESR2 Homo sapiens Human PF12497 PF00104 PF00105 6.5 IC50 ChEMBL
P08235 NR3C2 Homo sapiens Human PF00104 PF00105 6.5 IC50 ChEMBL;BindingDB
P10275 AR Homo sapiens Human PF02166 PF00104 PF00105 6.1 IC50 ChEMBL;BindingDB
Q96WX4 erg6 Pneumocystis carinii (strain B80) Pathogen PF08241 PF08498 6.5 pIC50 TTD_MultiTarget