Molecule Details
InChIKeyKGERZPVQIRYWRK-GDLZYMKVSA-N
Compound NameBms-986158
Canonical SMILESCc1nnn(C)c1-c1cnc2c3ccc(C(C)(C)O)cc3n([C@H](c3ccccc3)C3CCOCC3)c2c1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)4
Pfam Stratification Cross-Family
Avg pChEMBL8.98
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB15435
Drug NameBMS-986158
CAS Number1800340-40-2
Groups investigational
ATC Codes nan
DescriptionBMS-986158 is under investigation in clinical trial NCT02419417 (Study of BMS-986158 in Subjects With Select Advanced Cancers).

Cross-references: BindingDB: 297146 ChemSpider: 58828664 PDB: YWA
Target Activities (4)
Target Gene Organism Category Pfam pChEMBL Type Source
P01106 MYC Homo sapiens Human PF00010 PF02344 PF01056 9.2 IC50 ChEMBL;BindingDB
O60885 BRD4 Homo sapiens Human PF17035 PF17105 PF00439 9.0 IC50 ChEMBL;BindingDB
Q15059 BRD3 Homo sapiens Human PF17035 PF00439 9.0 IC50 ChEMBL;BindingDB
P25440 BRD2 Homo sapiens Human PF17035 PF00439 8.8 IC50 ChEMBL;BindingDB