InChIKey	KFQYTPMOWPVWEJ-INIZCTEOSA-N
Compound Name	Rotigotine
Canonical SMILES	CCCN(CCc1cccs1)[C@H]1CCc2c(O)cccc2C1
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	3
Pfam Stratification	Homologous
Avg pChEMBL	8.63
Source	ChEMBL;BindingDB

DrugBank ID	DB05271
Drug Name	Rotigotine
CAS Number	99755-59-6
Groups	approved investigational
ATC Codes	N04BC09
Description	Rotigotine (Neupro) is a non-ergoline dopamine agonist indicated for the treatment of Parkinson's disease (PD) and restless legs syndrome (RLS) in Europe and the United States. It is formulated as a once-daily transdermal patch which provides a slow and constant supply of the drug over the course of...

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Categories: Agents that produce hypertension Anti-Parkinson Agents (Dopamine Agonist) Anti-Parkinson Drugs Antidepressive Agents Central Nervous System Depressants Cytochrome P-450 CYP2C19 Inhibitors Cytochrome P-450 CYP2C19 Inhibitors (weak) Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (weak) Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Dopamine Agents Dopamine Agonists Hypotensive Agents Naphthalenes Nervous System Neurotransmitter Agents Nonergot-derivative Dopamine Receptor Agonists Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome Serotonin 5-HT1 Receptor Agonists Serotonin Agents Serotonin Receptor Agonists Sulfur Compounds

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Cross-references: BindingDB: 50123626 ChEBI: 135351 CHEMBL1303 ChemSpider: 53406 Drugs Product Database (DPD): 12548 Guide to Pharmacology: 941 IUPHAR: 941 D05768 PDB: R5F PharmGKB: PA166165149 PubChem:59227 PubChem:99443232 RxCUI: 616739 Wikipedia: Rotigotine ZINC: ZINC000000004028