Molecule Details
| InChIKey | JZFPYUNJRRFVQU-UHFFFAOYSA-N |
|---|---|
| Canonical SMILES | O=C(O)c1cccnc1Nc1cccc(C(F)(F)F)c1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 2 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.29 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB04552 |
|---|---|
| Drug Name | Niflumic acid |
| CAS Number | 4394-00-7 |
| Groups | investigational |
| ATC Codes | M02AA17 M01AX02 |
| Description | Niflumic acid is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis. |
Categories: Acids, Carbocyclic Agents causing hyperkalemia Agents that produce hypertension Aminobenzoates Analgesics Analgesics, Non-Narcotic Anti-Inflammatory Agents Anti-Inflammatory Agents, Non-Steroidal Antiinflammatory Preparations, Non-Steroids for Topical Use Antiinflammatory and Antirheumatic Products Antiinflammatory and Antirheumatic Products, Non-Steroids Antirheumatic Agents Benzene Derivatives Benzoates Cyclooxygenase Inhibitors Enzyme Inhibitors Fenamates Musculo-Skeletal System Nephrotoxic agents Nicotinic Acids Niflumic Acid and Prodrugs Peripheral Nervous System Agents Pyridines Selective Cyclooxygenase 2 Inhibitors (NSAIDs) Sensory System Agents Topical Products for Joint and Muscular Pain UGT1A9 Inhibitors ortho-Aminobenzoates
Cross-references: BindingDB: 85507 ChEBI: 34888 CHEMBL63323 ChemSpider: 4333 Guide to Pharmacology: 2439 IUPHAR: 2439 C13698 D08275 PDB: NFL PharmGKB: PA164746749 PubChem:4488 PubChem:46504657 RxCUI: 7418 Therapeutic Targets Database: DAP000972 Wikipedia: Niflumic_acid ZINC: ZINC000000125031
Target Activities (2)
DrugBank Target Actions (9)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| O60656 | O60656 | UDP-glucuronosyltransferase 1A9 | inhibitor | enzymes |
| O60656 | O60656 | UDP-glucuronosyltransferase 1A9 | binder | targets |
| P23219 | PTGS1 | Prostaglandin G/H synthase 1 | binder | targets |
| P47712 | PLA2G4A | Cytosolic phospholipase A2 | binder | targets |
| P51800 | P51800 | Chloride channel protein ClC-Ka | inducer | targets |
| P04054 | PLA2G1B | Phospholipase A2 | inhibitor | targets |
| P35354 | PTGS2 | Prostaglandin G/H synthase 2 | inhibitor | targets |
| O60669 | SLC16A7 | Monocarboxylate transporter 2 | inhibitor | transporters |
| P53985 | SLC16A1 | Monocarboxylate transporter 1 | inhibitor | transporters |