Molecule Details
| InChIKey | JYTNQNCOQXFQPK-MRXNPFEDSA-N |
|---|---|
| Compound Name | Suvorexant |
| Canonical SMILES | Cc1ccc(-n2nccn2)c(C(=O)N2CCN(c3nc4cc(Cl)ccc4o3)CC[C@H]2C)c1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 2 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 8.38 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB09034 |
|---|---|
| Drug Name | Suvorexant |
| CAS Number | 1030377-33-3 |
| Groups | approved investigational |
| ATC Codes | N05CJ01 |
| Description | Suvorexant is a selective dual antagonist of orexin receptors OX1R and OX2R that promotes sleep by reducing wakefulness and arousal. It has been approved for the treatment of insomnia. |
Categories: Central Nervous System Agents Central Nervous System Depressants Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A4 Substrates (strength unknown) Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Hypnotics and Sedatives Miscellaneous Anxiolytics Sedatives and Hypnotics Nervous System Neurotransmitter Agents Orexin Receptor Antagonists P-glycoprotein inhibitors Psycholeptics Sleep Aids, Pharmaceutical
Cross-references: BindingDB: 50318701 ChEBI: 82698 CHEMBL1083659 ChemSpider: 24662178 Drugs Product Database (DPD): 23022 D10082 PDB: SUV PubChem:24965990 PubChem:310264985 RxCUI: 1547099 Wikipedia: Suvorexant ZINC: ZINC000049036447