InChIKey	JVHXJTBJCFBINQ-ADAARDCZSA-N
Compound Name	Dapagliflozin
Canonical SMILES	CCOc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc2Cl)cc1
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	4
Pfam Stratification	Homologous
Avg pChEMBL	7.56
Source	BindingDB;ChEMBL

DrugBank ID	DB06292
Drug Name	Dapagliflozin
CAS Number	461432-26-8
Groups	approved investigational
ATC Codes	A10BK01 A10BD15 A10BD21 A10BD25 A10BD30 A10BD29
Description	Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2.[A261596] When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose re...

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Categories: Alimentary Tract and Metabolism Benzene Derivatives Blood Glucose Lowering Agents Carbohydrates Cytochrome P-450 CYP1A1 Substrates Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP2A6 Substrates Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Substrates Diuretics Drugs Used in Diabetes Glycosides Hypotensive Agents Oral Hypoglycemics P-glycoprotein substrates Sodium-Glucose Transport Proteins, antagonists & inhibitors Sodium-Glucose Transporter 2 Inhibitors Sodium-glucose Cotransporter 2 (SGLT2) Inhibitors UGT1A9 Substrates UGT2B7 substrates

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Cross-references: BindingDB: 50448927 ChEBI: 85078 CHEMBL429910 ChemSpider: 8063384 Drugs Product Database (DPD): 22549 D08897 PDB: LE6 PubChem:9887712 PubChem:175427068 RxCUI: 1488564 Wikipedia: Dapagliflozin ZINC: ZINC000003819138