3-[dideuterio-(3,3-difluoropyrrolidin-1-yl)methyl]-N-[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amine

InChIKey	`JVAFTPDILUBIGR-KNXIQCGSSA-N`
Compound Name	3-[dideuterio-(3,3-difluoropyrrolidin-1-yl)methyl]-N-[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amine
Canonical SMILES	`[2H]C([2H])(c1cc(Nc2nc(C)cn3c(-c4cn[nH]c4)cnc23)sn1)N1CCC(F)(F)C1`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	7
Pfam Stratification	Cross-Family
Avg pChEMBL	6.63
Source	ChEMBL

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P36888	FLT3	Homo sapiens	Human	PF00047 PF07714	7.3	IC50	ChEMBL
Q96GD4	AURKB	Homo sapiens	Human	PF00069	7.2	IC50	ChEMBL
O14757	CHEK1	Homo sapiens	Human	PF00069	6.7	IC50	ChEMBL
P35968	KDR	Homo sapiens	Human	PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854	6.5	IC50	ChEMBL
P06239	LCK	Homo sapiens	Human	PF07714 PF00017 PF00018	6.3	IC50	ChEMBL
Q9NWZ3	IRAK4	Homo sapiens	Human	PF07714	6.2	IC50	ChEMBL
P54760	EPHB4	Homo sapiens	Human	PF14575 PF25599 PF01404 PF07699 PF00041 PF07714 PF00536	6.2	IC50	ChEMBL