Molecule Details
| InChIKey | JTWJBADLHDCZDM-UHFFFAOYSA-N |
|---|---|
| Compound Name | N-[4-[[2-(3,5-difluoroanilino)-5-[1-(2-hydroxyethyl)pyrazol-4-yl]pyrimidin-4-yl]amino]cyclohexyl]-2,2,2-trifluoroacetamide |
| Canonical SMILES | O=C(NC1CCC(Nc2nc(Nc3cc(F)cc(F)c3)ncc2-c2cnn(CCO)c2)CC1)C(F)(F)F |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 3 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.68 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (3)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q12866 | MERTK | Homo sapiens | Human | PF00041 PF00047 PF13927 PF07714 | 9.1 | IC50 | ChEMBL;BindingDB |
| Q06418 | TYRO3 | Homo sapiens | Human | PF00041 PF07679 PF07714 | 7.3 | IC50 | ChEMBL;BindingDB |
| P30530 | AXL | Homo sapiens | Human | PF00041 PF13927 PF07714 | 6.7 | IC50 | ChEMBL;BindingDB |