Molecule Details
InChIKeyJTRNNNVASYCTLO-UHFFFAOYSA-N
Compound NameN-[2-chloro-5-[5-[2-(3-morpholin-4-ylanilino)pyrimidin-4-yl]imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]-2-phenylacetamide
Canonical SMILESO=C(Cc1ccccc1)Nc1cc(-c2nc3sccn3c2-c2ccnc(Nc3cccc(N4CCOCC4)c3)n2)ccc1Cl
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)14
Pfam Stratification Cross-Family
Avg pChEMBL6.8
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (14)
Target Gene Organism Category Pfam pChEMBL Type Source
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 7.9 Ki ChEMBL
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 7.7 Ki ChEMBL
P17948 FLT1 Homo sapiens Human PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 7.4 Ki ChEMBL
P06239 LCK Homo sapiens Human PF07714 PF00017 PF00018 7.1 Ki ChEMBL
Q13188 STK3 Homo sapiens Human PF11629 PF00069 7.0 Ki ChEMBL
O95819 MAP4K4 Homo sapiens Human PF00780 PF00069 6.8 Ki ChEMBL
P07333 CSF1R Homo sapiens Human PF00047 PF25305 PF07714 6.8 Ki ChEMBL
Q8N4C8 MINK1 Homo sapiens Human PF00780 PF00069 6.8 Ki ChEMBL
P08069 IGF1R Homo sapiens Human PF00757 PF07714 PF01030 6.7 Ki ChEMBL
P11362 FGFR1 Homo sapiens Human PF07679 PF00047 PF07714 6.4 Ki ChEMBL
Q9Y4K4 MAP4K5 Homo sapiens Human PF00780 PF00069 6.4 Ki ChEMBL
P06241 FYN Homo sapiens Human PF07714 PF00017 PF00018 6.1 Ki ChEMBL
Q7L7X3 TAOK1 Homo sapiens Human PF00069 6.1 Ki ChEMBL
P22607 FGFR3 Homo sapiens Human PF21165 PF07679 PF13927 PF07714 6.0 Ki ChEMBL