Molecule Details
| InChIKey | JTJMJGYZQZDUJJ-UHFFFAOYSA-N |
|---|---|
| Compound Name | Phencyclidine |
| Canonical SMILES | c1ccc(C2(N3CCCCC3)CCCCC2)cc1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 9 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.38 |
| Source | BindingDB;ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB03575 |
|---|---|
| Drug Name | Phencyclidine |
| CAS Number | 77-10-1 |
| Groups | experimental illicit |
| ATC Codes | nan |
| Description | A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to ketamine in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA r... |
Categories: Central Nervous System Agents Central Nervous System Depressants Cytochrome P-450 CYP2B6 Inhibitors Cytochrome P-450 CYP2B6 Inhibitors (strength unknown) Cytochrome P-450 Enzyme Inhibitors Enzyme Inhibitors Excitatory Amino Acid Agents Excitatory Amino Acid Antagonists Hallucinogens NMDA Receptor Antagonists Neurotransmitter Agents Phencyclidine, antagonists & inhibitors Piperidines Psychotropic Drugs
Cross-references: BindingDB: 83449 ChEBI: 8058 CHEMBL275528 ChemSpider: 6224 C07575 PDB: 1PC PharmGKB: PA128406980 PubChem:6468 PubChem:46508889 Wikipedia: Phencyclidine ZINC: ZINC000000968311
Target Activities (9)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| O15399 | GRIN2D | Homo sapiens | Human | PF01094 PF00060 PF10613 | 7.6 | Ki | ChEMBL |
| O60391 | GRIN3B | Homo sapiens | Human | PF00060 PF10613 | 7.6 | Ki | ChEMBL |
| Q05586 | GRIN1 | Homo sapiens | Human | PF01094 PF00060 PF10613 | 7.6 | Ki | ChEMBL |
| Q13224 | GRIN2B | Homo sapiens | Human | PF01094 PF00060 PF10613 PF10565 | 7.6 | Ki | ChEMBL |
| Q14957 | GRIN2C | Homo sapiens | Human | PF01094 PF00060 PF10613 PF10565 | 7.6 | Ki | ChEMBL |
| Q8TCU5 | GRIN3A | Homo sapiens | Human | PF01094 PF00060 PF10613 | 7.6 | Ki | ChEMBL |
| Q12879 | GRIN2A | Homo sapiens | Human | PF01094 PF00060 PF10613 PF10565 | 7.4 | IC50 | ChEMBL;BindingDB |
| P42785 | PRCP | Homo sapiens | Human | PF05577 | 7.0 | IC50 | ChEMBL;BindingDB |
| Q99720 | SIGMAR1 | Homo sapiens | Human | PF04622 | 6.1 | IC50 | ChEMBL;BindingDB |
DrugBank Target Actions (6)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P20813 | CYP2B6 | Cytochrome P450 2B6 | inhibitor | enzymes |
| Q8TCU5 | GRIN3A | Glutamate receptor ionotropic, NMDA 3A | antagonist | targets |
| Q99720 | SIGMAR1 | Sigma non-opioid intracellular receptor 1 | binder | targets |
| Q05586 | GRIN1 | Glutamate receptor ionotropic, NMDA 1 | inhibitor | targets |
| Q12879 | GRIN2A | Glutamate receptor ionotropic, NMDA 2A | inhibitor | targets |
| Q13224 | GRIN2B | Glutamate receptor ionotropic, NMDA 2B | inhibitor | targets |