Molecule Details
InChIKeyJTIFUJUJDWUQEV-LSDHHAIUSA-N
Compound NameUS10717746, Example 25
Canonical SMILESCC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3cnn4c3CC(C)(C)C4)c(F)cn2)C1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)12
Pfam Stratification Cross-Family
Avg pChEMBL7.0
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (12)
Target Gene Organism Category Pfam pChEMBL Type Source
O60563 CCNT1 Homo sapiens Human PF00134 PF21797 8.4 Kd ChEMBL;BindingDB
P50750 CDK9 Homo sapiens Human PF00069 8.0 IC50 ChEMBL;BindingDB
Q00526 CDK3 Homo sapiens Human PF00069 7.7 IC50 ChEMBL;BindingDB
P24864 CCNE1 Homo sapiens Human PF02984 PF00134 7.2 IC50 ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 7.2 IC50 ChEMBL;BindingDB
P06493 CDK1 Homo sapiens Human PF00069 7.0 IC50 ChEMBL;BindingDB
P14635 CCNB1 Homo sapiens Human PF02984 PF00134 7.0 IC50 ChEMBL
P11802 CDK4 Homo sapiens Human PF00069 6.5 IC50 ChEMBL;BindingDB
Q00534 CDK6 Homo sapiens Human PF00069 6.3 IC50 ChEMBL;BindingDB
P50613 CDK7 Homo sapiens Human PF00069 6.3 IC50 ChEMBL
P51946 CCNH Homo sapiens Human PF16899 PF00134 6.3 IC50 ChEMBL;BindingDB
P51948 MNAT1 Homo sapiens Human PF25811 PF06391 PF17121 6.3 IC50 ChEMBL