Molecule Details
InChIKeyJSDGKSMNPHJDFK-UHFFFAOYSA-N
Compound Name3-[4-amino-3-(1,3-benzodioxol-5-yl)thieno[3,2-c]pyridin-7-yl]-N-methylprop-2-enamide
Canonical SMILESCNC(=O)C=Cc1cnc(N)c2c(-c3ccc4c(c3)OCO4)csc12
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)35
Pfam Stratification Cross-Family
Avg pChEMBL6.99
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (35)
Target Gene Organism Category Pfam pChEMBL Type Source
P06241 FYN Homo sapiens Human PF07714 PF00017 PF00018 8.7 Ki ChEMBL
P12931 SRC Homo sapiens Human PF07714 PF00017 PF00018 8.1 Ki ChEMBL
P17948 FLT1 Homo sapiens Human PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 7.9 Ki ChEMBL
P51451 BLK Homo sapiens Human PF07714 PF00017 PF00018 7.9 Ki ChEMBL
P42685 FRK Homo sapiens Human PF07714 PF00017 PF00018 7.8 Ki ChEMBL
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 7.7 Ki ChEMBL
P29317 EPHA2 Homo sapiens Human PF14575 PF25599 PF01404 PF00041 PF07714 PF00536 7.7 Ki ChEMBL
Q06418 TYRO3 Homo sapiens Human PF00041 PF07679 PF07714 7.7 Ki ChEMBL
P07333 CSF1R Homo sapiens Human PF00047 PF25305 PF07714 7.5 Ki ChEMBL
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 7.5 Ki ChEMBL
O95819 MAP4K4 Homo sapiens Human PF00780 PF00069 7.4 Ki ChEMBL
P22607 FGFR3 Homo sapiens Human PF21165 PF07679 PF13927 PF07714 7.4 Ki ChEMBL
P11362 FGFR1 Homo sapiens Human PF07679 PF00047 PF07714 7.3 Ki ChEMBL
P23443 RPS6KB1 Homo sapiens Human PF00069 PF00433 7.1 Ki ChEMBL
Q96GD4 AURKB Homo sapiens Human PF00069 7.1 Ki ChEMBL
P07948 LYN Homo sapiens Human PF07714 PF00017 PF00018 7.0 Ki ChEMBL
Q8N4C8 MINK1 Homo sapiens Human PF00780 PF00069 7.0 Ki ChEMBL
P36888 FLT3 Homo sapiens Human PF00047 PF07714 6.9 Ki ChEMBL
Q06187 BTK Homo sapiens Human PF00779 PF00169 PF07714 PF00017 PF00018 6.9 Ki ChEMBL
Q13882 PTK6 Homo sapiens Human PF07714 PF00017 PF00018 6.9 Ki ChEMBL
Q9Y4K4 MAP4K5 Homo sapiens Human PF00780 PF00069 6.9 Ki ChEMBL
P06239 LCK Homo sapiens Human PF07714 PF00017 PF00018 6.8 Ki ChEMBL
P35916 FLT4 Homo sapiens Human PF07679 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 6.8 Ki ChEMBL
Q9NYL2 MAP3K20 Homo sapiens Human PF07714 PF07647 6.7 Ki ChEMBL
P53667 LIMK1 Homo sapiens Human PF00412 PF00595 PF07714 6.6 Ki ChEMBL
Q16288 NTRK3 Homo sapiens Human PF07679 PF00047 PF13855 PF16920 PF01462 PF07714 6.5 Ki ChEMBL
P43405 SYK Homo sapiens Human PF07714 PF00017 6.4 Ki ChEMBL
Q9H3Y6 SRMS Homo sapiens Human PF07714 PF00017 6.3 Ki ChEMBL
O00444 PLK4 Homo sapiens Human PF00069 PF18190 PF18409 6.1 Ki ChEMBL
O60674 JAK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.1 Ki ChEMBL
O94806 PRKD3 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.0 Ki ChEMBL
P30530 AXL Homo sapiens Human PF00041 PF13927 PF07714 6.0 Ki ChEMBL
P51955 NEK2 Homo sapiens Human PF00069 6.0 Ki ChEMBL
Q16620 NTRK2 Homo sapiens Human PF07679 PF13855 PF16920 PF01462 PF07714 6.0 Ki ChEMBL
Q7KZI7 MARK2 Homo sapiens Human PF02149 PF00069 PF00627 6.0 Ki ChEMBL