6-(5-bromo-2-hydroxyphenyl)-4-(5-methylthiophen-2-yl)-2-oxo-1H-pyridine-3-carbonitrile

InChIKey	`JRLSUZIPUYDUKX-UHFFFAOYSA-N`
Compound Name	6-(5-bromo-2-hydroxyphenyl)-4-(5-methylthiophen-2-yl)-2-oxo-1H-pyridine-3-carbonitrile
Canonical SMILES	`Cc1ccc(-c2cc(-c3cc(Br)ccc3O)[nH]c(=O)c2C#N)s1`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	22
Pfam Stratification	Cross-Family
Avg pChEMBL	6.19
Source	ChEMBL

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P17612	PRKACA	Homo sapiens	Human	PF00069	6.6	Ki	ChEMBL
P49841	GSK3B	Homo sapiens	Human	PF00069	6.5	Ki	ChEMBL
Q16288	NTRK3	Homo sapiens	Human	PF07679 PF00047 PF13855 PF16920 PF01462 PF07714	6.5	Ki	ChEMBL
P07333	CSF1R	Homo sapiens	Human	PF00047 PF25305 PF07714	6.4	Ki	ChEMBL
Q8IU85	CAMK1D	Homo sapiens	Human	PF00069	6.4	Ki	ChEMBL
P04629	NTRK1	Homo sapiens	Human	PF13855 PF16920 PF07714 PF18613	6.2	Ki	ChEMBL
P35968	KDR	Homo sapiens	Human	PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854	6.2	Ki	ChEMBL
P36888	FLT3	Homo sapiens	Human	PF00047 PF07714	6.2	Ki	ChEMBL
P51812	RPS6KA3	Homo sapiens	Human	PF00069 PF00433	6.2	Ki	ChEMBL
O60674	JAK2	Homo sapiens	Human	PF18379 PF18377 PF17887 PF07714 PF21990	6.1	Ki	ChEMBL
P07949	RET	Homo sapiens	Human	PF00028 PF07714 PF17756 PF17812 PF17813 PF22540	6.1	Ki	ChEMBL
P08069	IGF1R	Homo sapiens	Human	PF00757 PF07714 PF01030	6.1	Ki	ChEMBL
P45983	MAPK8	Homo sapiens	Human	PF00069	6.1	Ki	ChEMBL
Q04912	MST1R	Homo sapiens	Human	PF07714 PF01437 PF01403 PF01833	6.1	Ki	ChEMBL
Q06418	TYRO3	Homo sapiens	Human	PF00041 PF07679 PF07714	6.1	Ki	ChEMBL
Q13131	PRKAA1	Homo sapiens	Human	PF16579 PF21147 PF00069	6.1	Ki	ChEMBL
Q96GD4	AURKB	Homo sapiens	Human	PF00069	6.1	Ki	ChEMBL
Q9Y463	DYRK1B	Homo sapiens	Human	PF00069	6.1	Ki	ChEMBL
P11309	PIM1	Homo sapiens	Human	PF00069	6.0	Ki	ChEMBL
P11362	FGFR1	Homo sapiens	Human	PF07679 PF00047 PF07714	6.0	Ki	ChEMBL
P34947	GRK5	Homo sapiens	Human	PF00069 PF00615	6.0	Ki	ChEMBL
Q13464	ROCK1	Homo sapiens	Human	PF25346 PF00069 PF08912	6.0	Ki	ChEMBL