Molecule Details
InChIKeyJRLOPMVTMMPZMV-UHFFFAOYSA-N
Compound Name[3-[5-[(2,5-difluorophenyl)methyl]-2H-pyrazolo[3,4-b]pyridin-3-yl]phenyl]-(3-hydroxypiperidin-1-yl)methanone
Canonical SMILESO=C(c1cccc(-c2n[nH]c3ncc(Cc4cc(F)ccc4F)cc23)c1)N1CCCC(O)C1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)6
Pfam Stratification Cross-Family
Avg pChEMBL7.27
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (6)
Target Gene Organism Category Pfam pChEMBL Type Source
O96013 PAK4 Homo sapiens Human PF00786 PF00069 7.6 IC50 ChEMBL
O00444 PLK4 Homo sapiens Human PF00069 PF18190 PF18409 7.2 IC50 ChEMBL
P04629 NTRK1 Homo sapiens Human PF13855 PF16920 PF07714 PF18613 7.2 IC50 ChEMBL
Q05397 PTK2 Homo sapiens Human PF21477 PF00373 PF18038 PF03623 PF07714 7.2 IC50 ChEMBL
Q16288 NTRK3 Homo sapiens Human PF07679 PF00047 PF13855 PF16920 PF01462 PF07714 7.2 IC50 ChEMBL
Q16620 NTRK2 Homo sapiens Human PF07679 PF13855 PF16920 PF01462 PF07714 7.0 IC50 ChEMBL