Molecule Details
| InChIKey | JOTFMTSQZUIOAI-CHWSQXEVSA-N |
|---|---|
| Compound Name | 5-[(1R)-1-(3,5-dichloro-4-pyridinyl)ethoxy]-3-[5-fluoro-6-[(2R)-2-methylazetidin-1-yl]-3-pyridinyl]-6-methoxy-1H-indazole |
| Canonical SMILES | COc1cc2[nH]nc(-c3cnc(N4CC[C@H]4C)c(F)c3)c2cc1O[C@H](C)c1c(Cl)cncc1Cl |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.61 |
| Source | BindingDB |
2D Structure
Activity Profile
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P22455 | FGFR4 | Homo sapiens | Human | PF07679 PF13927 PF07714 | 8.0 | Kd | BindingDB |
| P22607 | FGFR3 | Homo sapiens | Human | PF21165 PF07679 PF13927 PF07714 | 8.0 | Kd | BindingDB |
| P11362 | FGFR1 | Homo sapiens | Human | PF07679 PF00047 PF07714 | 7.2 | Kd | BindingDB |
| P21802 | FGFR2 | Homo sapiens | Human | PF07679 PF13927 PF07714 | 7.2 | Kd | BindingDB |