InChIKey	JOOXLOJCABQBSG-UHFFFAOYSA-N
Compound Name	Fedratinib
Canonical SMILES	Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	139
Pfam Stratification	Cross-Family
Avg pChEMBL	6.68
Source	ChEMBL;BindingDB

DrugBank ID	DB12500
Drug Name	Fedratinib
CAS Number	936091-26-8
Groups	approved investigational
ATC Codes	G01AE10 L01EJ02
Description	Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative.[A183188] Fedratinib was granted FDA approval on August 16, 2019.[L8090]

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Categories: Amides Antineoplastic Agents Antineoplastic and Immunomodulating Agents BCRP/ABCG2 Inhibitors Benzene Derivatives Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (strength unknown) Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Genito Urinary System and Sex Hormones Gynecological Antiinfectives and Antiseptics Janus Kinase Inhibitor Kinase Inhibitor MATE 1 Inhibitors MATE 2 Inhibitors MATE inhibitors OATP1B1/SLCO1B1 Inhibitors OATP1B3 inhibitors P-glycoprotein inhibitors P-glycoprotein substrates Protein Kinase Inhibitors Sulfonamides Sulfones Sulfur Compounds Tyrosine Kinase Inhibitors

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Cross-references: BindingDB: 50332294 ChEBI: 91408 CHEMBL1287853 ChemSpider: 17626393 Drugs Product Database (DPD): 23489 PDB: 2TA PharmGKB: PA166280361 PubChem:16722836 PubChem:347828733 RxCUI: 2197490 Wikipedia: Fedratinib ZINC: ZINC000019862646