Molecule Details
InChIKeyJOMHSQGEWSNUKU-UHFFFAOYSA-N
Canonical SMILESCN(C)S(=O)(=O)c1ccc2c(c1)N(CCCN1CCC(CCO)CC1)c1ccccc1S2
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)2
Pfam Stratification Homologous
Avg pChEMBL9.62
SourceBindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB01621
Drug NamePipotiazine
CAS Number39860-99-6
Groups approved investigational withdrawn
ATC Codes N05AC04
DescriptionPipotiazine has actions similar to those of other phenothiazines. Among the different phenothiazine derivatives, it appears to be less sedating and to have a weak propensity for causing hypotension or potentiating the effects of CNS depressants and anesthetics. However, it produces a high incidence ...

Categories: Antidepressive Agents Antipsychotic Agents Central Nervous System Depressants Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (strength unknown) Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Dopamine Antagonists Dopamine D2 Receptor Antagonists Drugs causing inadvertant photosensitivity Heterocyclic Compounds, Fused-Ring Hyperglycemia-Associated Agents Nervous System Neurotoxic agents Phenothiazines Phenothiazines With Piperidine Structure Photosensitizing Agents Psycholeptics Serotonin 5-HT1 Receptor Antagonists Serotonin 5-HT1A Receptor Antagonists Serotonin 5-HT2 Receptor Antagonists Serotonin 5-HT2A Receptor Antagonists Serotonin Agents Serotonin Receptor Antagonists Sulfur Compounds
Cross-references: BindingDB: 81798 CHEMBL398880 ChemSpider: 56598 Drugs Product Database (DPD): 7968 D08385 PharmGKB: PA10158 PubChem:62867 PubChem:46508263 RxCUI: 8348 Wikipedia: Pipotiazine ZINC: ZINC000003813024
Target Activities (2)
Target Gene Organism Category Pfam pChEMBL Type Source
P14416 DRD2 Homo sapiens Human PF00001 9.7 Ki BindingDB
P35462 DRD3 Homo sapiens Human PF00001 9.6 Ki BindingDB
DrugBank Target Actions (10)
Target Gene Target Name Action Type
P02768 ALB Albumin binder carriers
P10635 CYP2D6 Cytochrome P450 2D6 inhibitor enzymes
P08684 CYP3A4 Cytochrome P450 3A4 substrate enzymes
P10635 CYP2D6 Cytochrome P450 2D6 substrate enzymes
P33261 CYP2C19 Cytochrome P450 2C19 substrate enzymes
P08908 HTR1A 5-hydroxytryptamine receptor 1A antagonist targets
P14416 DRD2 D(2) dopamine receptor antagonist targets
P21728 DRD1 D(1A) dopamine receptor antagonist targets
P28223 HTR2A 5-hydroxytryptamine receptor 2A antagonist targets
O15245 SLC22A1 Solute carrier family 22 member 1 binder transporters