Molecule Details
InChIKeyJNUGFGAVPBYSHF-UHFFFAOYSA-N
Compound NameL-778123
Canonical SMILESN#Cc1ccc(Cn2cncc2CN2CCN(c3cccc(Cl)c3)C(=O)C2)cc1
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)5
Pfam Stratification Cross-Family
Avg pChEMBL8.5
SourceChEMBL;BindingDB;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB07227
Drug NameL-778123
CAS Number183499-57-2
Groups experimental
ATC Codes nan
Descriptionnan

Cross-references: BindingDB: 50097071 CHEMBL279433 ChemSpider: 187601 PDB: 778 PubChem:216454 PubChem:99443698 ZINC: ZINC000053070632
Target Activities (5)
Target Gene Organism Category Pfam pChEMBL Type Source
P01111 NRAS Homo sapiens Human PF00071 9.5 Ki ChEMBL
P01112 HRAS Homo sapiens Human PF00071 8.8 Ki ChEMBL
P49354 FNTA Homo sapiens Human PF01239 8.7 pIC50 TTD_MultiTarget
P49356 FNTB Homo sapiens Human PF00432 8.5 IC50 ChEMBL;BindingDB
P53609 PGGT1B Homo sapiens Human PF00432 7.0 IC50 ChEMBL
DrugBank Target Actions (3)
Target Gene Target Name Action Type
P49354 FNTA Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha modulator targets
P49356 FNTB Protein farnesyltransferase subunit beta modulator targets
P53609 PGGT1B Geranylgeranyl transferase type-1 subunit beta modulator targets