Molecule Details
InChIKeyJMVDIGHUQAXWIE-UHFFFAOYSA-N
Compound NameN-[2-methyl-5-[2-oxo-9-(1H-pyrazol-4-yl)-1-benzo[h][1,6]naphthyridinyl]phenyl]-2-propenamide
Canonical SMILESC=CC(=O)Nc1cc(-n2c(=O)ccc3cnc4ccc(-c5cn[nH]c5)cc4c32)ccc1C
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)10
Pfam Stratification Cross-Family
Avg pChEMBL7.25
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (10)
Target Gene Organism Category Pfam pChEMBL Type Source
Q06187 BTK Homo sapiens Human PF00779 PF00169 PF07714 PF00017 PF00018 8.3 IC50 ChEMBL;BindingDB
P51813 BMX Homo sapiens Human PF00779 PF00169 PF07714 PF00017 8.1 IC50 ChEMBL;BindingDB
P42345 MTOR Homo sapiens Human PF02259 PF02260 PF08771 PF23593 PF11865 PF00454 7.7 IC50 ChEMBL;BindingDB
Q9HBH9 MKNK2 Homo sapiens Human PF00069 7.6 IC50 ChEMBL;BindingDB
P51451 BLK Homo sapiens Human PF07714 PF00017 PF00018 7.5 IC50 ChEMBL;BindingDB
P52333 JAK3 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 7.4 IC50 ChEMBL;BindingDB
Q9BUB5 MKNK1 Homo sapiens Human PF00069 7.0 IC50 ChEMBL;BindingDB
P49759 CLK1 Homo sapiens Human PF00069 6.4 IC50 ChEMBL
P49760 CLK2 Homo sapiens Human PF00069 6.4 IC50 ChEMBL;BindingDB
P49116 NR2C2 Homo sapiens Human PF00104 PF00105 6.1 IC50 ChEMBL;BindingDB