Molecule Details
InChIKeyJMPFSEBWVLAJKM-UHFFFAOYSA-N
Compound NameClosantel
Canonical SMILESCc1cc(C(C#N)c2ccc(Cl)cc2)c(Cl)cc1NC(=O)c1cc(I)cc(I)c1O
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)8
Pfam Stratification Cross-Family
Avg pChEMBL6.39
SourceChEMBL;BindingDB;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
Target Activities (8)
Target Gene Organism Category Pfam pChEMBL Type Source
P24557 TBXAS1 Homo sapiens Human PF00067 7.2 IC50 ChEMBL
P0DMS8 ADORA3 Homo sapiens Human PF00001 7.1 IC50 ChEMBL
P00533 EGFR Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 6.2 IC50 ChEMBL
P04626 ERBB2 Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 6.2 pIC50 TTD_MultiTarget
Q16539 MAPK14 Homo sapiens Human PF00069 6.2 IC50 ChEMBL
P18089 ADRA2B Homo sapiens Human PF00001 6.1 Ki ChEMBL
P06241 FYN Homo sapiens Human PF07714 PF00017 PF00018 6.0 IC50 ChEMBL
P18825 ADRA2C Homo sapiens Human PF00001 6.0 Ki ChEMBL