Molecule Details
InChIKeyJMNJYGMAUMANNW-FIXZTSJVSA-N
Compound NameDynorphin A (swine)
Canonical SMILESCC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)O
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)3
Pfam Stratification Homologous
Avg pChEMBL8.64
SourceBindingDB;ChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB16146
Drug NameDynorphin
CAS Number80448-90-4
Groups investigational
ATC Codes nan
DescriptionDynorphin is under investigation in clinical trial NCT00000244 (Effects of Dynorphin 1-13 on Heroin Addiction - 1).

Categories: Amino Acids, Peptides, and Proteins Nerve Tissue Proteins Neuropeptides Neurotransmitter Agents Opioid Peptides Peptides Proteins
Cross-references: CHEMBL411557 ChemSpider: 17290383 Wikipedia: Dynorphin
Target Activities (3)
Target Gene Organism Category Pfam pChEMBL Type Source
P41145 OPRK1 Homo sapiens Human PF00001 9.3 Ki ChEMBL;BindingDB
P41143 OPRD1 Homo sapiens Human PF00001 8.6 IC50 ChEMBL;BindingDB
P35372 OPRM1 Homo sapiens Human PF00001 8.0 Ki ChEMBL;BindingDB
DrugBank Target Actions (3)
Target Gene Target Name Action Type
P35372 OPRM1 Mu-type opioid receptor inhibitor targets
P41143 OPRD1 Delta-type opioid receptor inhibitor targets
P41145 OPRK1 Kappa-type opioid receptor inhibitor targets