Molecule Details
InChIKeyJLUUVUUYIXBDCG-UHFFFAOYSA-N
Canonical SMILESCNc1nc(-c2nc3ccc(N4CCN(C)CC4)cc3n2Cc2ccccc2)cn2c(C)nnc12
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)2
Pfam Stratification Cross-Family
Avg pChEMBL8.05
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB21566
Drug NameAmredobresib
CAS Number1610044-98-8
Groups investigational
ATC Codes nan
DescriptionAmredobresib is a small molecule drug. The usage of the INN stem '-bresib' in the name indicates that Amredobresib is a inhibitor of the bromodomain and extra-terminal motif (BET) family of bromodomain (BRD) protein, antineoplastic. Amredobresib is under investigation in clinical trial NCT02516553 (...

Cross-references: BindingDB: 209472 CHEMBL3919831 PDB: ZHO
Target Activities (2)
Target Gene Organism Category Pfam pChEMBL Type Source
O60885 BRD4 Homo sapiens Human PF17035 PF17105 PF00439 8.1 IC50 ChEMBL;BindingDB
P62805 H4C1 Homo sapiens Human PF15511 8.1 IC50 ChEMBL