Molecule Details
InChIKeyJKZZCHSVFXZBAI-UHFFFAOYSA-N
Compound NameBcr-abl-IN-6
Canonical SMILESNc1n[nH]c2cccc(C#Cc3cccc(NC(=O)c4ccc(N5CCOCC5)c(C(F)(F)F)c4)c3)c12
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)6
Pfam Stratification Cross-Family
Avg pChEMBL7.19
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (6)
Target Gene Organism Category Pfam pChEMBL Type Source
P07333 CSF1R Homo sapiens Human PF00047 PF25305 PF07714 7.8 IC50 ChEMBL;BindingDB
P00519 ABL1 Homo sapiens Human PF08919 PF07714 PF00017 PF00018 7.5 IC50 ChEMBL;BindingDB
P11274 BCR Homo sapiens Human PF09036 PF00168 PF19057 PF00620 PF00621 7.5 IC50 ChEMBL
P12931 SRC Homo sapiens Human PF07714 PF00017 PF00018 7.2 IC50 ChEMBL;BindingDB
P15056 BRAF Homo sapiens Human PF00130 PF07714 PF02196 6.9 IC50 ChEMBL;BindingDB
P36888 FLT3 Homo sapiens Human PF00047 PF07714 6.3 IC50 ChEMBL;BindingDB