N-(2-chloro-4-methylthiophen-3-yl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide

InChIKey	`JKDJAOQUTMBBQB-UHFFFAOYSA-N`
Compound Name	N-(2-chloro-4-methylthiophen-3-yl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide
Canonical SMILES	`Cc1nc(Nc2ncc(C(=O)Nc3c(C)csc3Cl)s2)cc(N2CCN(CCO)CC2)n1`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	5
Pfam Stratification	Cross-Family
Avg pChEMBL	7.92
Source	BindingDB;ChEMBL

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P00519	ABL1	Homo sapiens	Human	PF08919 PF07714 PF00017 PF00018	8.3	IC50	ChEMBL;BindingDB
P14867	GABRA1	Homo sapiens	Human	PF02931 PF02932	8.3	IC50	BindingDB
P57059	SIK1	Homo sapiens	Human	PF00069 PF23312	7.9	IC50	ChEMBL;BindingDB
Q9H0K1	SIK2	Homo sapiens	Human	PF00069 PF23312	7.8	IC50	ChEMBL;BindingDB
Q9Y2K2	SIK3	Homo sapiens	Human	PF00069 PF23312	7.4	IC50	ChEMBL;BindingDB