Molecule Details
| InChIKey | JIVPVXMEBJLZRO-AWEZNQCLSA-N |
|---|---|
| Compound Name | 2-chloro-5-((1S)-1-hydroxy-3-oxo-2H-isoindol-1-yl)benzenesulfonamide |
| Canonical SMILES | NS(=O)(=O)c1cc([C@@]2(O)NC(=O)c3ccccc32)ccc1Cl |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 8 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.34 |
| Source | BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB08046 |
|---|---|
| Drug Name | 2-chloro-5-[(1S)-1-hydroxy-3-oxo-2H-isoindol-1-yl]benzenesulfonamide |
| CAS Number | 1441368-51-9 |
| Groups | experimental |
| ATC Codes | nan |
| Description | nan |
Cross-references: CHEMBL402262 ChemSpider: 599888 PDB: KLT PubChem:688424 PubChem:99444517 ZINC: ZINC000000057255
Target Activities (8)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P43166 | CA7 | Homo sapiens | Human | PF00194 | 8.6 | Ki | BindingDB |
| O43570 | CA12 | Homo sapiens | Human | PF00194 | 8.3 | Ki | BindingDB |
| Q9Y2D0 | CA5B | Homo sapiens | Human | PF00194 | 8.1 | Ki | BindingDB |
| Q16790 | CA9 | Homo sapiens | Human | PF00194 | 7.6 | Ki | BindingDB |
| P00918 | CA2 | Homo sapiens | Human | PF00194 | 6.9 | Ki | BindingDB |
| P22748 | CA4 | Homo sapiens | Human | PF00194 | 6.7 | Ki | BindingDB |
| P00915 | CA1 | Homo sapiens | Human | PF00194 | 6.5 | IC50 | BindingDB |
| P35218 | CA5A | Homo sapiens | Human | PF00194 | 6.0 | Ki | BindingDB |
DrugBank Target Actions (1)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P00918 | CA2 | Carbonic anhydrase 2 | binder | targets |