Molecule Details
InChIKeyJGWTVBVOISUVJD-UHFFFAOYSA-N
Compound NameN-[[3-[3-[2-(hydroxycarbamoyl)piperidin-1-yl]sulfonylpropoxy]phenyl]methyl]-4-oxo-3H-quinazoline-2-carboxamide
Canonical SMILESO=C(NCc1cccc(OCCCS(=O)(=O)N2CCCCC2C(=O)NO)c1)c1nc2ccccc2c(=O)[nH]1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)9
Pfam Stratification Cross-Family
Avg pChEMBL8.23
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (9)
Target Gene Organism Category Pfam pChEMBL Type Source
P45452 MMP13 Homo sapiens Human PF00045 PF00413 PF01471 10.3 IC50 ChEMBL;BindingDB
P08253 MMP2 Homo sapiens Human PF00040 PF00045 PF00413 9.2 IC50 ChEMBL;BindingDB
P22894 MMP8 Homo sapiens Human PF00045 PF00413 PF01471 8.9 IC50 ChEMBL;BindingDB
P39900 MMP12 Homo sapiens Human PF00045 PF00413 PF01471 8.7 IC50 ChEMBL;BindingDB
P08254 MMP3 Homo sapiens Human PF00045 PF00413 PF01471 8.6 IC50 ChEMBL;BindingDB
P09238 MMP10 Homo sapiens Human PF00045 PF00413 PF01471 8.6 IC50 ChEMBL;BindingDB
P14780 MMP9 Homo sapiens Human PF00040 PF00045 PF00413 7.1 IC50 ChEMBL;BindingDB
P78536 ADAM17 Homo sapiens Human PF16698 PF00200 PF13574 6.3 IC50 ChEMBL;BindingDB
P50281 MMP14 Homo sapiens Human PF11857 PF00045 PF00413 PF01471 6.3 IC50 ChEMBL;BindingDB