Molecule Details
| InChIKey | JFPVXVDWJQMJEE-IZRZKJBUSA-N |
|---|---|
| Compound Name | Cefuroxime |
| Canonical SMILES | CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(COC(N)=O)CS[C@H]12)c1ccco1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 3 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.65 |
| Source | BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB01112 |
|---|---|
| Drug Name | Cefuroxime |
| CAS Number | 55268-75-2 |
| Groups | approved investigational |
| ATC Codes | S01AA27 J01DC02 J01RA03 |
| Description | Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, gonorrhea, and haemophilus. |
Categories: Amides Anti-Bacterial Agents Anti-Infective Agents Antibacterials for Systemic Use Antiinfectives for Systemic Use Cephalosporins Heterocyclic Compounds, Fused-Ring Lactams Nephrotoxic agents Ophthalmologicals Second-Generation Cephalosporins Sensory Organs Sulfur Compounds Thiazines beta-Lactams
Cross-references: BindingDB: 50422689 ChEBI: 3515 CHEMBL1436 ChemSpider: 4586393 Drugs Product Database (DPD): 11118 C06894 D00262 PDB: KOV PharmGKB: PA448868 PubChem:5479529 PubChem:46506681 RxCUI: 2194 Therapeutic Targets Database: DAP000445 Wikipedia: Cefuroxime ZINC: ZINC000003871978
Target Activities (3)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P14677 | pbpX | Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) | Pathogen | PF03793 PF03717 PF00905 | 7.9 | IC50 | BindingDB |
| Q04707 | ponA | Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) | Pathogen | PF00912 PF00905 | 7.8 | IC50 | BindingDB |
| P0A3M5 | penA | Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) | Pathogen | PF03717 PF00905 | 7.2 | IC50 | BindingDB |