Molecule Details
InChIKeyJFIBVDBTCDTBRH-REZTVBANSA-N
Canonical SMILESCC(C)=CCC/C(C)=C/CNCCNC1C2CC3CC(C2)CC1C3
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)2
Pfam Stratification Homologous
Avg pChEMBL6.29
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB05186
Drug NameSQ-109
CAS Number502487-67-4
Groups investigational
ATC Codes nan
DescriptionSQ-109 is an orally active, small molecule antibiotic for treatment of pulmonary TB. Currently in Phase I clinical trials, SQ-109 could replace one or more drugs in the current first-line TB drug regimen, simplify therapy, and shorten the TB treatment regimen.

Categories: Amines Bridged-Ring Compounds Cycloparaffins Diamines Polyamines
Cross-references: BindingDB: 50388398 CHEMBL561057 ChemSpider: 4438718 PubChem:5274428 PubChem:175426955 ZINC: ZINC000039959796
Target Activities (2)
Target Gene Organism Category Pfam pChEMBL Type Source
P37268 FDFT1 Homo sapiens Human PF00494 6.1 Ki ChEMBL;BindingDB
A9JQL9 crtM Staphylococcus aureus Pathogen PF00494 6.4 Ki ChEMBL;BindingDB