Molecule Details
InChIKeyJDUBGYFRJFOXQC-QGZVFWFLSA-N
Compound Name(R)-Capivasertib
Canonical SMILESNC1(C(=O)N[C@H](CCO)c2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)5
Pfam Stratification Homologous
Avg pChEMBL7.26
SourceBindingDB;ChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (5)
Target Gene Organism Category Pfam pChEMBL Type Source
Q9Y243 AKT3 Homo sapiens Human PF00169 PF00069 PF00433 8.0 IC50 BindingDB
P31751 AKT2 Homo sapiens Human PF00169 PF00069 PF00433 7.9 IC50 BindingDB
O75116 ROCK2 Homo sapiens Human PF25346 PF00069 PF08912 7.1 IC50 BindingDB
P31749 AKT1 Homo sapiens Human PF00169 PF00069 PF00433 7.0 IC50 ChEMBL;BindingDB
Q13464 ROCK1 Homo sapiens Human PF25346 PF00069 PF08912 6.3 IC50 BindingDB