Molecule Details
InChIKeyJCFJQIHDZHHMQT-UHFFFAOYSA-N
Compound Name7-((2-oxopyrrolidin-1-yl)methyl)pyrrolo[1,2-a]quinoxalin-4(5H)-one
Canonical SMILESO=C1CCCN1Cc1ccc2c(c1)[nH]c(=O)c1cccn12
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)42
Pfam Stratification Cross-Family
Avg pChEMBL6.57
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (42)
Target Gene Organism Category Pfam pChEMBL Type Source
Q06418 TYRO3 Homo sapiens Human PF00041 PF07679 PF07714 7.6 Ki ChEMBL
Q13131 PRKAA1 Homo sapiens Human PF16579 PF21147 PF00069 7.5 Ki ChEMBL
O14965 AURKA Homo sapiens Human PF00069 7.4 Ki ChEMBL
P04626 ERBB2 Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 7.4 Ki ChEMBL
P49841 GSK3B Homo sapiens Human PF00069 7.3 Ki ChEMBL
P53350 PLK1 Homo sapiens Human PF00069 PF00659 7.1 Ki ChEMBL
P68400 CSNK2A1 Homo sapiens Human PF00069 7.1 Ki ChEMBL
Q9H4B4 PLK3 Homo sapiens Human PF00069 PF00659 7.1 Ki ChEMBL
P31749 AKT1 Homo sapiens Human PF00169 PF00069 PF00433 6.9 Ki ChEMBL
P51812 RPS6KA3 Homo sapiens Human PF00069 PF00433 6.9 Ki ChEMBL
Q8IW41 MAPKAPK5 Homo sapiens Human PF00069 6.9 Ki ChEMBL
Q9NR20 DYRK4 Homo sapiens Human PF00069 6.9 Ki ChEMBL
Q16644 MAPKAPK3 Homo sapiens Human PF00069 6.8 Ki ChEMBL
Q96PF2 TSSK2 Homo sapiens Human PF00069 6.8 Ki ChEMBL
P49840 GSK3A Homo sapiens Human PF00069 6.7 Ki ChEMBL
O15530 PDPK1 Homo sapiens Human PF14593 PF00069 6.6 Ki ChEMBL
P49137 MAPKAPK2 Homo sapiens Human PF00069 6.6 Ki ChEMBL
P51817 PRKX Homo sapiens Human PF00069 6.6 Ki ChEMBL
P08922 ROS1 Homo sapiens Human PF00041 PF07714 6.5 Ki ChEMBL
P17948 FLT1 Homo sapiens Human PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 6.5 Ki ChEMBL
P31751 AKT2 Homo sapiens Human PF00169 PF00069 PF00433 6.5 Ki ChEMBL
Q9Y243 AKT3 Homo sapiens Human PF00169 PF00069 PF00433 6.5 Ki ChEMBL
O95819 MAP4K4 Homo sapiens Human PF00780 PF00069 6.4 Ki ChEMBL
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 6.4 Ki ChEMBL
P08069 IGF1R Homo sapiens Human PF00757 PF07714 PF01030 6.4 Ki ChEMBL
P42679 MATK Homo sapiens Human PF07714 PF00017 PF00018 6.4 Ki ChEMBL
Q06187 BTK Homo sapiens Human PF00779 PF00169 PF07714 PF00017 PF00018 6.4 Ki ChEMBL
Q9H2X6 HIPK2 Homo sapiens Human PF00069 6.4 Ki ChEMBL
P51955 NEK2 Homo sapiens Human PF00069 6.3 Ki ChEMBL
O94806 PRKD3 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.2 Ki ChEMBL
P09874 PARP1 Homo sapiens Human PF00533 PF21728 PF00644 PF02877 PF05406 PF00645 PF08063 6.2 Ki ChEMBL;BindingDB
O00311 CDC7 Homo sapiens Human PF00069 6.1 Ki ChEMBL
O15264 MAPK13 Homo sapiens Human PF00069 6.1 Ki ChEMBL
P04629 NTRK1 Homo sapiens Human PF13855 PF16920 PF07714 PF18613 6.1 Ki ChEMBL
P06241 FYN Homo sapiens Human PF07714 PF00017 PF00018 6.1 Ki ChEMBL
Q14680 MELK Homo sapiens Human PF02149 PF00069 PF21594 6.1 Ki ChEMBL
O00444 PLK4 Homo sapiens Human PF00069 PF18190 PF18409 6.0 Ki ChEMBL
P51617 IRAK1 Homo sapiens Human PF00531 PF00069 6.0 Ki ChEMBL
P53778 MAPK12 Homo sapiens Human PF00069 6.0 Ki ChEMBL
Q13237 PRKG2 Homo sapiens Human PF00027 PF00069 6.0 Ki ChEMBL
Q13976 PRKG1 Homo sapiens Human PF00027 PF16808 PF00069 6.0 Ki ChEMBL
Q9BZL6 PRKD2 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.0 Ki ChEMBL