InChIKey	JCCNYMKQOSZNPW-UHFFFAOYSA-N
Compound Name	Loratadine
Canonical SMILES	CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	4
Pfam Stratification	Cross-Family
Avg pChEMBL	7.0
Source	ChEMBL

DrugBank ID	DB00455
Drug Name	Loratadine
CAS Number	79794-75-5
Groups	approved investigational
ATC Codes	R06AX13
Description	Loratadine is a second generation antihistamine used to manage symptoms of allergic rhinitis.[A176435] A lack of sedative and CNS adverse effects make loratadine, along with other second generation antihistamines, preferable over their 1st generation counterparts in many clinical situations.[A176441...

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Categories: Anti-Allergic Agents Antihistamines for Systemic Use Antipruritics BSEP/ABCB11 Substrates Benzocycloheptenes Cytochrome P-450 CYP1A1 Substrates Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP2B6 Substrates Cytochrome P-450 CYP2C19 Inhibitors Cytochrome P-450 CYP2C19 Inhibitors (weak) Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (moderate) Cytochrome P-450 CYP2C8 Substrates Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (weak) Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (weak) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Dermatologicals Dibenzocycloheptenes Histamine Antagonists Histamine H1 Antagonists Histamine H1 Antagonists, Non-Sedating Loratadine and derivatives Neurotransmitter Agents P-glycoprotein inhibitors P-glycoprotein substrates Piperidines Potential QTc-Prolonging Agents QTc Prolonging Agents

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Cross-references: BindingDB: 50637414 ChEBI: 6538 CHEMBL998 ChemSpider: 3820 Drugs Product Database (DPD): 1299 D00364 PharmGKB: PA450266 PubChem:3957 PubChem:46507853 RxCUI: 28889 Therapeutic Targets Database: DAP000101 Wikipedia: Loratadine ZINC: ZINC000000537931