Molecule Details
InChIKeyJBRASADWXDKCLJ-UHFFFAOYSA-N
Compound Name5-Benzoyl-4-(4-chlorophenyl)-6-oxo-2-phenyl-1-cyclohexene-1-carbonitrile
Canonical SMILESN#CC1=C(c2ccccc2)CC(c2ccc(Cl)cc2)C(C(=O)c2ccccc2)C1=O
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)22
Pfam Stratification Cross-Family
Avg pChEMBL6.31
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (22)
Target Gene Organism Category Pfam pChEMBL Type Source
O14757 CHEK1 Homo sapiens Human PF00069 7.0 Ki ChEMBL
P53667 LIMK1 Homo sapiens Human PF00412 PF00595 PF07714 6.8 Ki ChEMBL
P08581 MET Homo sapiens Human PF07714 PF01437 PF01403 PF01833 6.6 Ki ChEMBL
P51955 NEK2 Homo sapiens Human PF00069 6.6 Ki ChEMBL
O14965 AURKA Homo sapiens Human PF00069 6.5 Ki ChEMBL
P45984 MAPK9 Homo sapiens Human PF00069 6.5 Ki ChEMBL
P45983 MAPK8 Homo sapiens Human PF00069 6.4 Ki ChEMBL
P49336 CDK8 Homo sapiens Human PF00069 6.4 Ki ChEMBL
P50750 CDK9 Homo sapiens Human PF00069 6.4 Ki ChEMBL
Q8IU85 CAMK1D Homo sapiens Human PF00069 6.4 Ki ChEMBL
P04629 NTRK1 Homo sapiens Human PF13855 PF16920 PF07714 PF18613 6.3 Ki ChEMBL
P11309 PIM1 Homo sapiens Human PF00069 6.3 Ki ChEMBL
P36507 MAP2K2 Homo sapiens Human PF00069 6.3 Ki ChEMBL
P49841 GSK3B Homo sapiens Human PF00069 6.3 Ki ChEMBL
Q9HAZ1 CLK4 Homo sapiens Human PF00069 6.1 Ki ChEMBL
P11362 FGFR1 Homo sapiens Human PF07679 PF00047 PF07714 6.0 Ki ChEMBL
P51812 RPS6KA3 Homo sapiens Human PF00069 PF00433 6.0 Ki ChEMBL
Q02750 MAP2K1 Homo sapiens Human PF00069 6.0 Ki ChEMBL
Q06418 TYRO3 Homo sapiens Human PF00041 PF07679 PF07714 6.0 Ki ChEMBL
Q12851 MAP4K2 Homo sapiens Human PF00780 PF00069 6.0 Ki ChEMBL
Q16288 NTRK3 Homo sapiens Human PF07679 PF00047 PF13855 PF16920 PF01462 PF07714 6.0 Ki ChEMBL
Q9Y463 DYRK1B Homo sapiens Human PF00069 6.0 Ki ChEMBL