Molecule Details
| InChIKey | JBHLOPKIPKTRSU-UHFFFAOYSA-N |
|---|---|
| Compound Name | [2-(6-chloropyridin-3-yl)-4-(2-methoxyethoxy)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-imidazo[1,5-a]pyridin-1-ylmethanone |
| Canonical SMILES | COCCOc1nc(-c2ccc(Cl)nc2)nc2c1CN(C(=O)c1ncn3ccccc13)CC2 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.46 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q9Y233 | PDE10A | Homo sapiens | Human | PF01590 PF00233 | 9.0 | Ki | ChEMBL;BindingDB |
| P16499 | PDE6A | Homo sapiens | Human | PF01590 PF00233 | 7.4 | Ki | ChEMBL |
| O76074 | PDE5A | Homo sapiens | Human | PF01590 PF00233 | 6.9 | Ki | ChEMBL |
| Q9HCR9 | PDE11A | Homo sapiens | Human | PF01590 PF00233 | 6.5 | Ki | ChEMBL |